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pubmed-article:8996526pubmed:abstractTextThe pharmacokinetics of 5-fluorouracil (5-FU) in different animal species treated with the dihydropyrimidine dehydrogenase (DPD) inactivator, 5-ethynyluracil (776C85) were related through allometric scaling. Estimates of 5-FU dose in combination with 776C85 were determined from pharmacokinetic and toxicodynamic analysis.lld:pubmed
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pubmed-article:8996526pubmed:articleTitleDihydropyrimidine dehydrogenase inactivation and 5-fluorouracil pharmacokinetics: allometric scaling of animal data, pharmacokinetics and toxicodynamics of 5-fluorouracil in humans.lld:pubmed
pubmed-article:8996526pubmed:affiliationGlaxo Wellcome Inc., Research Triangle Park, NC 27709, USA.lld:pubmed
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