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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1997-2-6
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pubmed:abstractText |
The pharmacokinetics of 5-fluorouracil (5-FU) in different animal species treated with the dihydropyrimidine dehydrogenase (DPD) inactivator, 5-ethynyluracil (776C85) were related through allometric scaling. Estimates of 5-FU dose in combination with 776C85 were determined from pharmacokinetic and toxicodynamic analysis.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:issn |
0344-5704
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
233-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8996526-Animals,
pubmed-meshheading:8996526-Antimetabolites, Antineoplastic,
pubmed-meshheading:8996526-Dihydrouracil Dehydrogenase (NADP),
pubmed-meshheading:8996526-Dogs,
pubmed-meshheading:8996526-Fluorouracil,
pubmed-meshheading:8996526-Humans,
pubmed-meshheading:8996526-Mice,
pubmed-meshheading:8996526-Models, Chemical,
pubmed-meshheading:8996526-Oxidoreductases,
pubmed-meshheading:8996526-Rats,
pubmed-meshheading:8996526-Uracil
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pubmed:year |
1997
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|
pubmed:articleTitle |
Dihydropyrimidine dehydrogenase inactivation and 5-fluorouracil pharmacokinetics: allometric scaling of animal data, pharmacokinetics and toxicodynamics of 5-fluorouracil in humans.
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pubmed:affiliation |
Glaxo Wellcome Inc., Research Triangle Park, NC 27709, USA.
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pubmed:publicationType |
Journal Article
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