Linked Life Data

8994833

Source:http://linkedlifedata.com/resource/pubmed/id/8994833

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1997-2-27
pubmed:abstractText
The negative factor (Nef) of human and simian immunodeficiency viruses (HIV-1, HIV-2 and SIV) is required for high levels of viremia and progression to AIDS. Additionally, Nef leads to cellular activation, increased viral infectivity and decreased expression of CD4 on the cell surface. Previously, we and others demonstrated that Nef associates with a cellular serine kinase (NAK) activity. Recently, it was demonstrated that NAK bears structural and functional similarity to p21-activated kinases (PAKs).
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins, http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/GTP Phosphohydrolases, http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Gene Products, nef, http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Serum Response Factor, http://linkedlifedata.com/resource/pubmed/chemical/cdc42 GTP-Binding Protein, http://linkedlifedata.com/resource/pubmed/chemical/nef Gene Products, Human..., http://linkedlifedata.com/resource/pubmed/chemical/p21-Activated Kinases, http://linkedlifedata.com/resource/pubmed/chemical/rac GTP-Binding Proteins
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0960-9822
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1677-84
pubmed:dateRevised
2007-11-19
pubmed:meshHeading
pubmed-meshheading:8994833-3T3 Cells, pubmed-meshheading:8994833-Animals, pubmed-meshheading:8994833-COS Cells, pubmed-meshheading:8994833-Cell Cycle Proteins, pubmed-meshheading:8994833-Cell Line, pubmed-meshheading:8994833-DNA-Binding Proteins, pubmed-meshheading:8994833-GTP Phosphohydrolases, pubmed-meshheading:8994833-GTP-Binding Proteins, pubmed-meshheading:8994833-Gene Expression Regulation, pubmed-meshheading:8994833-Gene Products, nef, pubmed-meshheading:8994833-HIV-1, pubmed-meshheading:8994833-Humans, pubmed-meshheading:8994833-Jurkat Cells, pubmed-meshheading:8994833-Mice, pubmed-meshheading:8994833-Nuclear Proteins, pubmed-meshheading:8994833-Protein-Serine-Threonine Kinases, pubmed-meshheading:8994833-Rats, pubmed-meshheading:8994833-Serum Response Factor, pubmed-meshheading:8994833-Signal Transduction, pubmed-meshheading:8994833-Virus Replication, pubmed-meshheading:8994833-cdc42 GTP-Binding Protein, pubmed-meshheading:8994833-nef Gene Products, Human Immunodeficiency Virus, pubmed-meshheading:8994833-p21-Activated Kinases, pubmed-meshheading:8994833-rac GTP-Binding Proteins
pubmed:year
1996
pubmed:articleTitle
CDC42 and Rac1 are implicated in the activation of the Nef-associated kinase and replication of HIV-1.
pubmed:affiliation
Howard Hughes Medical Institute, University of California at San Francisco, California, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't