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pubmed-article:8994778pubmed:abstractTextbeta-Lactamases are the principal mechanism of bacterial resistance to beta-lactam antibiotics. In recent years the number and variety of new beta-lactamases detected has risen at an alarming rate, apparently in response to the clinical use of novel classes of beta-lactam antibiotics. This paper reviews the structure and evolution of beta-lactamases in an attempt to understand the pressures that have contributed to their emergence.lld:pubmed
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pubmed-article:8994778pubmed:articleTitleEvolution and dissemination of beta-lactamases accelerated by generations of beta-lactam antibiotics.lld:pubmed
pubmed-article:8994778pubmed:affiliationMiriam Hospital, Brown University, Providence, Rhode Island 02906, USA.lld:pubmed
pubmed-article:8994778pubmed:publicationTypeJournal Articlelld:pubmed
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