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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
1997-3-19
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pubmed:abstractText |
beta-Lactamases are the principal mechanism of bacterial resistance to beta-lactam antibiotics. In recent years the number and variety of new beta-lactamases detected has risen at an alarming rate, apparently in response to the clinical use of novel classes of beta-lactam antibiotics. This paper reviews the structure and evolution of beta-lactamases in an attempt to understand the pressures that have contributed to their emergence.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1058-4838
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
24 Suppl 1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
S19-45
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pubmed:dateRevised |
2004-11-18
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pubmed:meshHeading |
pubmed-meshheading:8994778-Anti-Bacterial Agents,
pubmed-meshheading:8994778-Bacteria,
pubmed-meshheading:8994778-Molecular Structure,
pubmed-meshheading:8994778-Protein Structure, Tertiary,
pubmed-meshheading:8994778-Structure-Activity Relationship,
pubmed-meshheading:8994778-beta-Lactam Resistance,
pubmed-meshheading:8994778-beta-Lactamases,
pubmed-meshheading:8994778-beta-Lactams
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pubmed:year |
1997
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pubmed:articleTitle |
Evolution and dissemination of beta-lactamases accelerated by generations of beta-lactam antibiotics.
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pubmed:affiliation |
Miriam Hospital, Brown University, Providence, Rhode Island 02906, USA.
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pubmed:publicationType |
Journal Article,
Review
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