Linked Life Data

89944

Source:http://linkedlifedata.com/resource/pubmed/id/89944

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1979-11-29
pubmed:abstractText
The ability of cortisone to modify EEG and seizure activity was investigated in the baboon, Papio papio. Acute intramuscular doses (0.5-4 mg/kg) caused a dose-dependent increase in seizure response to a flashing light stimulus. This increase in seizure response was apparent in both seizure duration and the spread of convulsive activity. Along with enhancement of seizures, cortisone was found to cause marked changes in the EEG, ranging from the appearance of interictal paroxysmal activity to alterations in spectral characteristics of the wave forms. Increases in slow waves appeared concomitant with a decrease in fast activity in the 18-25 c/sec range. Since previous studies have indicated that seizure proclivity in the Papio papio is maximal at the time of the day when cortisol excretion rates peak, these findings lend further evidence to the idea that corticosteroids may be involved in the thythmic variation of seizure activity in the baboon.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0013-4694
pubmed:author
pubmed:issnType
Print
pubmed:volume
47
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
404-10
pubmed:dateRevised
2008-9-9
pubmed:meshHeading
pubmed:year
1979
pubmed:articleTitle
The influence of cortisone on EEG and seizure activity in the baboon Papio papio.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.