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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1997-4-2
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pubmed:abstractText |
Optic nerve stimulation has been reported to evoke a field potential (FP) in rat suprachiasmatic nucleus (SCN) slices. Methylcobalamin,delta-(5,6-dymethylbenzimidazolyl)-Co-methyl-cobam ide (Me-B12) enhanced this FP and the enhancement lasted more than 1 h after washing out. Maximal enhancement (143.6 +/- 9.8%) was achieved at a concentration of 10 microM. By contrast, cyanocobalamin containing CN- instead of CH3- showed no enhancement of the amplitude in the FP. Me-B12 induced enhancement of FP was strongly blocked by an N-methyl-D-aspartate (NMDA) receptor antagonist, DL-2-amino-5-phosphonovaleric acid (APV). These results indicate that CH3- in the Me-B12 is required to modulate the FP amplitude and the NMDA receptor is involved in the long-lasting FP enhancement induced by Me-B12. The present results suggest that Me-B12 modifies the photic entrainment of the circadian clock in the suprachiasmatic nucleus via an activation of NMDA receptors.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0304-3940
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
220
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
199-202
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:8994227-2-Amino-5-phosphonovalerate,
pubmed-meshheading:8994227-Animals,
pubmed-meshheading:8994227-Electric Stimulation,
pubmed-meshheading:8994227-Evoked Potentials,
pubmed-meshheading:8994227-Excitatory Amino Acid Agonists,
pubmed-meshheading:8994227-Excitatory Amino Acid Antagonists,
pubmed-meshheading:8994227-Excitatory Amino Acids,
pubmed-meshheading:8994227-N-Methylaspartate,
pubmed-meshheading:8994227-Optic Nerve,
pubmed-meshheading:8994227-Rats,
pubmed-meshheading:8994227-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:8994227-Stimulation, Chemical,
pubmed-meshheading:8994227-Suprachiasmatic Nucleus,
pubmed-meshheading:8994227-Vitamin B 12
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pubmed:year |
1996
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pubmed:articleTitle |
Methylcobalamin induces a long-lasting enhancement of the field potential in rat suprachiasmatic nucleus slices.
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pubmed:affiliation |
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
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pubmed:publicationType |
Journal Article
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