Linked Life Data

8993112

Source:http://linkedlifedata.com/resource/pubmed/id/8993112

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1997-2-27
pubmed:abstractText
The serum level of human ventricular myosin light chains 1 and 2 was determined by competitive ELISA assay in 56 patients, of whom 26 with acute myocardial infarction (18 with simple AMI and 8 with complex AMI), 10 with unstable angina pectoris and 20 healthy subjects. The serum level of human ventricular myosin light chains 1 and 2 (HVMLC1 and HVMLC2) in healthy subjects was of 6-10 ng/ml. Sensitivity of the assay was 10 ng/ml, and the working range was 10-100 ng/ml. In all AMI patients the HVMLC1 serum level exceeded 2-3 times the reference range within the first 24 hours after the onset of chest pain, the mean (+/- ISD) peak concentration was of 45.7 (+/- 13.6) ng/ml (simple AMI) and 64.22 (+/- 18.5 ng/ml) (severe AMI) 48 hours after infarction and it remained significantly higher than the normal value for another 7-10 days after the onset of infarction. The serum HVMLC2 concentration exceeded 10 ng/ml 48 hours after infarction, with a mean (+/- 1SD) peak concentration of 37.8 (+/- 10.4) ng/ml (simple AMI) and 53.8 (+/- 16.1) ng/ml (complex AMI) 90 hours after the onset of infarction and remained at high values for another 4-7 days. In two of ten patients with unstable angina pectoris LC2 increases above 10 ng/ml. The prolonged release of HVMLC1 and HVMLC2 in serum for 4-7 days after the onset of myocardial infarction may facilitate the retroactive detection of infarction, hence the extension of myocardium necrosis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1222-3891
pubmed:author
pubmed:issnType
Print
pubmed:volume
54
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
31-42
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Level of ventricular myosin light chains 1 and 2 determined by ELISA in serum of patients with acute myocardial infarction.
pubmed:affiliation
Cantacuzino Institute, Immunochemistry Laboratory, Bucharest, Romania.
pubmed:publicationType
Journal Article, Comparative Study