Nine new polyacetylenes, triangulynes A-H (1-8) and triangulynic acid (9), have been isolated from the marine sponge Pellina triangulata (Oceanapiidae) through cytotoxicity-guided fractionation. Structural elucidations and stereochemistry assignments were based on chemical and spectral studies.
Laboratory of Drug Discovery Research adn Development, Developmental Therapeutics Program, Division of Cancer Treatment, Diagnosis and Centers, National Cancer Institute, Frederick, MD 21702-1201.
