|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1997-2-13
|
|
pubmed:abstractText |
A Lac- strain of Escherichia coli that reverts by the addition of a G to a G-G-G-G-G-G sequence was used to study the proliferation of mutators in a bacterial culture. Selection for the Lac+ phenotype, which is greatly stimulated in mismatch repair-deficient strains, results in an increase in the percentage of mutators in the selected population from less than 1 per 100,000 cells to 1 per 200 cells. All the mutators detected were deficient in the mismatch repair system. Mutagenesis results in a similar increase in the percentage of mutators. Mutagenesis combined with a single selection can result in a population of more than 50% mutators when a sample of several thousand cells is grown out and selected. Mutagenesis combined with two or more successive selections can generate a population that is 100% mutator. These experiments are discussed in relation to ideas that an early step in carcinogenesis is the creation of a mutator phenotype.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8990293-1092652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8990293-1310899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8990293-13160960,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8990293-1333888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8990293-1370826,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8990293-14408281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8990293-16578437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8990293-17247902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8990293-1730743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8990293-1752431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8990293-2039987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8990293-2199309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8990293-3128795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8990293-4576119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8990293-4590472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8990293-4603159,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8990293-4614067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8990293-4879569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8990293-4914168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8990293-4919752,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8990293-5338974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8990293-7019693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8990293-7693660,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8990293-7761852,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8990293-7902574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8990293-7923117,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8990293-797306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8990293-8090721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8990293-8128251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8990293-8145827,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8990293-8252616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8990293-8261515,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8990293-8367721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8990293-8905093,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8990293-959840
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0021-9193
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
179
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
417-22
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
|
|
pubmed:year |
1997
|
|
pubmed:articleTitle |
Proliferation of mutators in A cell population.
|
|
pubmed:affiliation |
Department of Microbiology and Molecular Genetics, University of California, Los Angeles 90024, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
