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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1997-1-31
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pubmed:abstractText |
A number of studies have implicated a proline-directed protein kinase, glycogen synthase kinase-3 (GSK-3) in the hyperphosphorylation of tau in Alzheimer's disease (AD). Toward understanding the role of GSK-3 in the abnormal hyperphosphorylation of tau in AD we have found that GSK-3 is prominently present in neuronal cell bodies and their processes and co-localizes with neurofibrillary changes in AD brain. Furthermore, the levels of GSK-3 as determined by indirect ELISA are approximately 50% increased in the postsynaptosomal supernatant from AD brains as compared to the controls. However, no increase in GSK-3 enzyme activity was detected. In AD brain, with its reduced phosphatase activity, even normal levels of GSK-3 activity might be sufficient for the hyperphosphorylation of tau.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-3069
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
70-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:8990130-Alzheimer Disease,
pubmed-meshheading:8990130-Animals,
pubmed-meshheading:8990130-Brain,
pubmed-meshheading:8990130-Calcium-Calmodulin-Dependent Protein Kinases,
pubmed-meshheading:8990130-Cattle,
pubmed-meshheading:8990130-Cerebral Cortex,
pubmed-meshheading:8990130-Glycogen Synthase Kinase 3,
pubmed-meshheading:8990130-Glycogen Synthase Kinases,
pubmed-meshheading:8990130-Hippocampus,
pubmed-meshheading:8990130-Humans,
pubmed-meshheading:8990130-Nerve Tissue Proteins,
pubmed-meshheading:8990130-Neurofibrillary Tangles,
pubmed-meshheading:8990130-Neurons,
pubmed-meshheading:8990130-Phosphoprotein Phosphatases,
pubmed-meshheading:8990130-Phosphorylation,
pubmed-meshheading:8990130-Protein Processing, Post-Translational,
pubmed-meshheading:8990130-Recombinant Proteins,
pubmed-meshheading:8990130-tau Proteins
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pubmed:year |
1997
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pubmed:articleTitle |
Distribution, levels, and activity of glycogen synthase kinase-3 in the Alzheimer disease brain.
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pubmed:affiliation |
NYS Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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