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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1997-3-19
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pubmed:abstractText |
We have developed a comparative study of antigenic and immunogenic properties of selected immunodominant HIV-1 epitopes from p24 and gp120 proteins added to C-terminally truncated hepatitis B virus (HBV) core protein and exposed on the surface of chimeric core particles. Inserted p24 (121-210) and gp120/MN (306-328) epitopes induced the appropriate humoral and cellular immune responses against HIV-1. Superficially exposed region 160-192 of p24 also showed maximal B cell immunogenicity whereas buried region 148-162 induced maximal T cell response. Both recombinant proteins were also able to be recognized in vitro by T lymphocytes of HIV-1 asymptomatic carriers.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0889-2229
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
41-51
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8989426-AIDS Vaccines,
pubmed-meshheading:8989426-Adult,
pubmed-meshheading:8989426-Amino Acid Sequence,
pubmed-meshheading:8989426-Animals,
pubmed-meshheading:8989426-Female,
pubmed-meshheading:8989426-HIV Antibodies,
pubmed-meshheading:8989426-HIV Core Protein p24,
pubmed-meshheading:8989426-HIV Envelope Protein gp120,
pubmed-meshheading:8989426-HIV Infections,
pubmed-meshheading:8989426-HIV-1,
pubmed-meshheading:8989426-Hepatitis B Core Antigens,
pubmed-meshheading:8989426-Hepatitis B virus,
pubmed-meshheading:8989426-Humans,
pubmed-meshheading:8989426-Immunodominant Epitopes,
pubmed-meshheading:8989426-Male,
pubmed-meshheading:8989426-Mice,
pubmed-meshheading:8989426-Mice, Inbred BALB C,
pubmed-meshheading:8989426-Mice, Inbred C57BL,
pubmed-meshheading:8989426-Molecular Sequence Data,
pubmed-meshheading:8989426-Peptide Fragments,
pubmed-meshheading:8989426-Rabbits,
pubmed-meshheading:8989426-Recombinant Fusion Proteins,
pubmed-meshheading:8989426-T-Lymphocytes
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pubmed:year |
1997
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pubmed:articleTitle |
Relationship between antigenicity and immunogenicity of chimeric hepatitis B virus core particles carrying HIV type 1 epitopes.
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pubmed:affiliation |
Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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