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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1997-2-3
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pubmed:abstractText |
Increased homocysteine levels are a risk factor for atherosclerosis and its sequelae. A common genetic mutation in methylenetetrahydrofolate reductase (MTHFR), an enzyme required for efficient homocysteine metabolism, creates a thermolabile enzyme with reduced activity. We determined the prevalence of this mutation in many subjects with and without vascular disease and related it to homocysteine and folate levels.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0009-7322
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
94
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3074-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8989110-Adult,
pubmed-meshheading:8989110-Age of Onset,
pubmed-meshheading:8989110-Aged,
pubmed-meshheading:8989110-Base Sequence,
pubmed-meshheading:8989110-Blood Donors,
pubmed-meshheading:8989110-Canada,
pubmed-meshheading:8989110-DNA Primers,
pubmed-meshheading:8989110-Gene Frequency,
pubmed-meshheading:8989110-Genotype,
pubmed-meshheading:8989110-Homocysteine,
pubmed-meshheading:8989110-Homozygote,
pubmed-meshheading:8989110-Humans,
pubmed-meshheading:8989110-Infant, Newborn,
pubmed-meshheading:8989110-Methylenetetrahydrofolate Reductase (NADPH2),
pubmed-meshheading:8989110-Middle Aged,
pubmed-meshheading:8989110-Oxidoreductases Acting on CH-NH Group Donors,
pubmed-meshheading:8989110-Point Mutation,
pubmed-meshheading:8989110-Polymerase Chain Reaction,
pubmed-meshheading:8989110-Reference Values,
pubmed-meshheading:8989110-Regression Analysis,
pubmed-meshheading:8989110-Vascular Diseases
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pubmed:year |
1996
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pubmed:articleTitle |
Common mutation in methylenetetrahydrofolate reductase. Correlation with homocysteine metabolism and late-onset vascular disease.
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pubmed:affiliation |
Department of Medicine, Oregon Health Sciences University, Portland 97201-3098, USA. delought@ccmail.ohsu.edu
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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