Linked Life Data

8988843

Source:http://linkedlifedata.com/resource/pubmed/id/8988843

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1997-3-19
pubmed:abstractText
The bystander effect, in which unmodified cells are killed as the result of enzyme-prodrug activation in genetically modified neighboring cells, amplifies the suicide response in a tumor in which only a fraction of the cells are targeted. The drug verapamil (VRP), a calcium channel antagonist that is also used to counteract the multidrug resistance of tumor cells, is shown to inhibit the bystander effect by herpes simplex virus thymidine kinase (HSVtk) enzyme-prodrug therapy with ganciclovir by protecting beta geo marked bystander cells in both in vitro coculture assays and in an in vivo animal tumor model. VRP had no stimulatory or inhibitory effect on the proliferation of CT 26 cells, their tumorigenicity, or prodrug-activated cell death produced by the action of the HSVtk gene. The kinetics of the protection afforded by VRP was time dependent with respect to the time of addition of the prodrug, and protection was ineffective when added two or more days after prodrug administration.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0929-1903
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
405-12
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
The drug verapamil inhibits bystander killing but not cell suicide in thymidine kinase-ganciclovir prodrug-activated gene therapy.
pubmed:affiliation
Department of Experimental Pathology, University of Texas M.D. Anderson Cancer Center, Houston, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't