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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1997-3-25
|
| pubmed:databankReference | |
| pubmed:abstractText |
The sequence of a new B*39 allele has been identified in a South African Zulu individual. This allele designated B*3910, differs at two nucleotide positions (246 and 272) from B*39011. The difference at position 246 is silent, while that at position 272 results in an amino acid change from cysteine (B*39011) to tyrosine (B*3910). As these same differences are found in other HLA-B alleles, they were probably introduced into the B*3910 sequence by a short gene conversion event with another allele. This finding provides further evidence for the diversification of HLA-B allelic sequences via recombination.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0001-2815
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
48
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
595-7
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:8988545-Alleles,
pubmed-meshheading:8988545-Amino Acid Sequence,
pubmed-meshheading:8988545-HLA-B Antigens,
pubmed-meshheading:8988545-Humans,
pubmed-meshheading:8988545-Molecular Sequence Data,
pubmed-meshheading:8988545-Recombination, Genetic,
pubmed-meshheading:8988545-South Africa
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
A novel recombinant HLA-B*39 allele (B*3910) in a South African Zulu.
|
| pubmed:affiliation |
Department of Structural Biology, Stanford University School of Medicine, California, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|