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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1997-1-29
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pubmed:abstractText |
A group of bacterial protein toxins interfere with vesicular trafficking inside cells. Clostridial neurotoxins affect mainly the highly regulated fusion of neurotransmitter- and hormone-containing vesicles with the plasma membrane. They cleave the three SNARE proteins: VAMP, SNAP-25 and syntaxin, and this selective proteolysis results in a blockade of exocytosis. The Helicobacter pylori cytotoxin is implicated in the pathogenesis of gastroduodenal ulcers. It causes a progressive and extensive vacuolation of cells followed by necrosis, after a cytotoxin-induced alteration of membrane trafficking by late endosomes. Vacuoles originate from this compartment in a rab7-dependent process and swell because they are acidic and accumulate membrane-permeant amines.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0014-4754
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1026-32
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8988242-Bacterial Toxins,
pubmed-meshheading:8988242-Exocytosis,
pubmed-meshheading:8988242-Helicobacter pylori,
pubmed-meshheading:8988242-Membrane Fusion,
pubmed-meshheading:8988242-Membrane Proteins,
pubmed-meshheading:8988242-Models, Biological,
pubmed-meshheading:8988242-Nerve Tissue Proteins,
pubmed-meshheading:8988242-Peptic Ulcer,
pubmed-meshheading:8988242-Qa-SNARE Proteins,
pubmed-meshheading:8988242-SNARE Proteins,
pubmed-meshheading:8988242-Synaptosomal-Associated Protein 25,
pubmed-meshheading:8988242-Vesicular Transport Proteins
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pubmed:year |
1996
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pubmed:articleTitle |
Bacterial protein toxins and cell vesicle trafficking.
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pubmed:affiliation |
Centro CNR Biomembrane, Università di Padova, Italy. toxin@cribi1.bio.unipd.it
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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