Linked Life Data

8987666

Source:http://linkedlifedata.com/resource/pubmed/id/8987666

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1997-2-27
pubmed:abstractText
The water-soluble polysaccharide fraction from Gracilaria verrucosa (GWS) has been reported to increase the phagocytic activity of mice [Yoshizawa et al., Nippon Shokuhin Kogyo Gakkaishi, 41, 557-560 (1994)]. In this study, the macrophage-stimulation activity of enzyme-degraded GWS (GWS-E) was investigated by intraperitoneally and orally administering GWS-E to mice. The intraperitoneal administration of GWS-E increased the number of peritoneal exudate cells (PEC), and increased the phagocytic activity and oxygen radical-secreting activity (spontaneous chemiluminescence) of PEC. This administration could also stimulate splenic macrophages (SPM), increasing radical-secreting activity. When GWS-E was administered orally, the radical-secreting activity of PEC and SPM increased. In this case of oral administration, the activity of SPM increased in a dose-dependent manner, while that of PEC had an optimum dose. These results indicate that GWS-E had macrophage-stimulation activity in vivo and would be suitable as a source for a physiologically functional food with protective and immunopotentiating activity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
B
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0916-8451
pubmed:author
pubmed:issnType
Print
pubmed:volume
60
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1667-71
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
In vivo macrophage-stimulation activity of the enzyme-degraded water-soluble polysaccharide fraction from a marine alga (Gracilaria verrucosa).
pubmed:affiliation
Research and Development Center, Showa Sangyo Co., Ltd., Chiba, Japan.
pubmed:publicationType
Journal Article