Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
26
pubmed:dateCreated
1997-1-28
pubmed:databankReference
pubmed:abstractText
The (X;1)(p11;q21) translocation is a recurrent chromosomal abnormality in a subset of human papillary renal cell carcinomas, and is sometimes the sole cytogenetic abnormality present. Via positional cloning, we were able to identify the genes involved. The translocation results in a fusion of the transcription factor TFE3 gene on the X chromosome to a novel gene, designated PRCC, on chromosome 1. Through this fusion, reciprocal translocation products are formed, which are both expressed in papillary renal cell carcinomas. PRCC is ubiquitously expressed in normal adult and fetal tissues and encodes a putative protein of 491 aa with a relatively high content of prolines. No relevant homologies with known sequences at either the DNA or the protein level were found.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8986805-1321916, http://linkedlifedata.com/resource/pubmed/commentcorrection/8986805-1684532, http://linkedlifedata.com/resource/pubmed/commentcorrection/8986805-1685140, http://linkedlifedata.com/resource/pubmed/commentcorrection/8986805-3004698, http://linkedlifedata.com/resource/pubmed/commentcorrection/8986805-6324578, http://linkedlifedata.com/resource/pubmed/commentcorrection/8986805-6772444, http://linkedlifedata.com/resource/pubmed/commentcorrection/8986805-73185, http://linkedlifedata.com/resource/pubmed/commentcorrection/8986805-7587394, http://linkedlifedata.com/resource/pubmed/commentcorrection/8986805-7656211, http://linkedlifedata.com/resource/pubmed/commentcorrection/8986805-7664242, http://linkedlifedata.com/resource/pubmed/commentcorrection/8986805-7773963, http://linkedlifedata.com/resource/pubmed/commentcorrection/8986805-7797069, http://linkedlifedata.com/resource/pubmed/commentcorrection/8986805-7969446, http://linkedlifedata.com/resource/pubmed/commentcorrection/8986805-8187067, http://linkedlifedata.com/resource/pubmed/commentcorrection/8986805-8221618, http://linkedlifedata.com/resource/pubmed/commentcorrection/8986805-8370620, http://linkedlifedata.com/resource/pubmed/commentcorrection/8986805-8406438, http://linkedlifedata.com/resource/pubmed/commentcorrection/8986805-8431910, http://linkedlifedata.com/resource/pubmed/commentcorrection/8986805-8493574, http://linkedlifedata.com/resource/pubmed/commentcorrection/8986805-8527383, http://linkedlifedata.com/resource/pubmed/commentcorrection/8986805-8598045, http://linkedlifedata.com/resource/pubmed/commentcorrection/8986805-8682500, http://linkedlifedata.com/resource/pubmed/commentcorrection/8986805-8872474
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins, http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Fv1 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Muscle Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins, http://linkedlifedata.com/resource/pubmed/chemical/PRCC protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Prcc protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Proteins, http://linkedlifedata.com/resource/pubmed/chemical/TEAD4 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/TEFR1 protein, isoform b, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Tead4 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators, http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
24
pubmed:volume
93
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
15294-8
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:8986805-Adult, pubmed-meshheading:8986805-Amino Acid Sequence, pubmed-meshheading:8986805-Animals, pubmed-meshheading:8986805-Base Sequence, pubmed-meshheading:8986805-Carcinoma, Papillary, pubmed-meshheading:8986805-Carcinoma, Renal Cell, pubmed-meshheading:8986805-Cell Cycle Proteins, pubmed-meshheading:8986805-Chromosome Mapping, pubmed-meshheading:8986805-Chromosomes, Human, Pair 1, pubmed-meshheading:8986805-Cloning, Molecular, pubmed-meshheading:8986805-Cricetinae, pubmed-meshheading:8986805-DNA-Binding Proteins, pubmed-meshheading:8986805-Fetus, pubmed-meshheading:8986805-Gene Expression, pubmed-meshheading:8986805-Humans, pubmed-meshheading:8986805-Hybrid Cells, pubmed-meshheading:8986805-Kidney Neoplasms, pubmed-meshheading:8986805-Mice, pubmed-meshheading:8986805-Molecular Sequence Data, pubmed-meshheading:8986805-Muscle Proteins, pubmed-meshheading:8986805-Neoplasm Proteins, pubmed-meshheading:8986805-Polymerase Chain Reaction, pubmed-meshheading:8986805-Protein Biosynthesis, pubmed-meshheading:8986805-Proteins, pubmed-meshheading:8986805-Trans-Activators, pubmed-meshheading:8986805-Transcription Factors, pubmed-meshheading:8986805-Translocation, Genetic, pubmed-meshheading:8986805-X Chromosome
pubmed:year
1996
pubmed:articleTitle
Fusion of the transcription factor TFE3 gene to a novel gene, PRCC, in t(X;1)(p11;q21)-positive papillary renal cell carcinomas.
pubmed:affiliation
Department of Human Genetics, University Hospital Nijmegen, The Netherlands.
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