| pubmed-article:8986743 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8986743 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:8986743 | lifeskim:mentions | umls-concept:C0002395 | lld:lifeskim |
| pubmed-article:8986743 | lifeskim:mentions | umls-concept:C0025936 | lld:lifeskim |
| pubmed-article:8986743 | lifeskim:mentions | umls-concept:C0078939 | lld:lifeskim |
| pubmed-article:8986743 | lifeskim:mentions | umls-concept:C0872078 | lld:lifeskim |
| pubmed-article:8986743 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
| pubmed-article:8986743 | lifeskim:mentions | umls-concept:C0596988 | lld:lifeskim |
| pubmed-article:8986743 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:8986743 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8986743 | pubmed:dateCreated | 1997-1-31 | lld:pubmed |
| pubmed-article:8986743 | pubmed:abstractText | The mechanism by which mutations in the presenilin (PS) genes cause the most aggressive form of early-onset Alzheimer's disease (AD) is unknown, but fibroblasts from mutation carriers secrete increased levels of the amyloidogenic A beta 42 peptide, the main component of AD plaques. We established transfected cell and transgenic mouse models that coexpress human PS and amyloid beta-protein precursor (APP) genes and analyzed quantitatively the effects of PS expression on APP processing. In both models, expression of wild-type PS genes did not alter APP levels, alpha- and beta-secretase activity and A beta production. In the transfected cells, PS1 and PS2 mutations caused a highly significant increase in A beta 42 secretion in all mutant clones. Likewise, mutant but not wildtype PS1 transgenic mice showed significant overproduction of A beta 42 in the brain, and this effect was detectable as early as 2-4 months of age. Different PS mutations had differential effects on A beta generation. The extent of A beta 42 increase did not correlate with presenilin expression levels. Our data demonstrate that the presenilin mutations cause a dominant gain of function and may induce AD by enhancing A beta 42 production, thus promoting cerebral beta-amyloidosis. | lld:pubmed |
| pubmed-article:8986743 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8986743 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8986743 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8986743 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8986743 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8986743 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8986743 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8986743 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8986743 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8986743 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8986743 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8986743 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8986743 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8986743 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8986743 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8986743 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8986743 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8986743 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8986743 | pubmed:issn | 1078-8956 | lld:pubmed |
| pubmed-article:8986743 | pubmed:author | pubmed-author:LeaII | lld:pubmed |
| pubmed-article:8986743 | pubmed:author | pubmed-author:KimSS | lld:pubmed |
| pubmed-article:8986743 | pubmed:author | pubmed-author:DavisAA | lld:pubmed |
| pubmed-article:8986743 | pubmed:author | pubmed-author:SelkoeD JDJ | lld:pubmed |
| pubmed-article:8986743 | pubmed:author | pubmed-author:PerryBB | lld:pubmed |
| pubmed-article:8986743 | pubmed:author | pubmed-author:FraserPP | lld:pubmed |
| pubmed-article:8986743 | pubmed:author | pubmed-author:MottesMM | lld:pubmed |
| pubmed-article:8986743 | pubmed:author | pubmed-author:CarlsonGG | lld:pubmed |
| pubmed-article:8986743 | pubmed:author | pubmed-author:LieberburgII | lld:pubmed |
| pubmed-article:8986743 | pubmed:author | pubmed-author:SchenkDD | lld:pubmed |
| pubmed-article:8986743 | pubmed:author | pubmed-author:WestawayDD | lld:pubmed |
| pubmed-article:8986743 | pubmed:author | pubmed-author:YaoHH | lld:pubmed |
| pubmed-article:8986743 | pubmed:author | pubmed-author:LevesqueGG | lld:pubmed |
| pubmed-article:8986743 | pubmed:author | pubmed-author:XieSS | lld:pubmed |
| pubmed-article:8986743 | pubmed:author | pubmed-author:RommensJJ | lld:pubmed |
| pubmed-article:8986743 | pubmed:author | pubmed-author:SeubertPP | lld:pubmed |
| pubmed-article:8986743 | pubmed:author | pubmed-author:CitronMM | lld:pubmed |
| pubmed-article:8986743 | pubmed:author | pubmed-author:SherringtonRR | lld:pubmed |
| pubmed-article:8986743 | pubmed:author | pubmed-author:Johnson-WoodK... | lld:pubmed |
| pubmed-article:8986743 | pubmed:author | pubmed-author:DiehlTT | lld:pubmed |
| pubmed-article:8986743 | pubmed:author | pubmed-author:KholodenkoDD | lld:pubmed |
| pubmed-article:8986743 | pubmed:author | pubmed-author:St George... | lld:pubmed |
| pubmed-article:8986743 | pubmed:author | pubmed-author:StromeRR | lld:pubmed |
| pubmed-article:8986743 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8986743 | pubmed:volume | 3 | lld:pubmed |
| pubmed-article:8986743 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8986743 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8986743 | pubmed:pagination | 67-72 | lld:pubmed |
| pubmed-article:8986743 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:8986743 | pubmed:meshHeading | pubmed-meshheading:8986743-... | lld:pubmed |
| pubmed-article:8986743 | pubmed:meshHeading | pubmed-meshheading:8986743-... | lld:pubmed |
| pubmed-article:8986743 | pubmed:meshHeading | pubmed-meshheading:8986743-... | lld:pubmed |
| pubmed-article:8986743 | pubmed:meshHeading | pubmed-meshheading:8986743-... | lld:pubmed |
| pubmed-article:8986743 | pubmed:meshHeading | pubmed-meshheading:8986743-... | lld:pubmed |
| pubmed-article:8986743 | pubmed:meshHeading | pubmed-meshheading:8986743-... | lld:pubmed |
| pubmed-article:8986743 | pubmed:meshHeading | pubmed-meshheading:8986743-... | lld:pubmed |
| pubmed-article:8986743 | pubmed:meshHeading | pubmed-meshheading:8986743-... | lld:pubmed |
| pubmed-article:8986743 | pubmed:meshHeading | pubmed-meshheading:8986743-... | lld:pubmed |
| pubmed-article:8986743 | pubmed:meshHeading | pubmed-meshheading:8986743-... | lld:pubmed |
| pubmed-article:8986743 | pubmed:meshHeading | pubmed-meshheading:8986743-... | lld:pubmed |
| pubmed-article:8986743 | pubmed:meshHeading | pubmed-meshheading:8986743-... | lld:pubmed |
| pubmed-article:8986743 | pubmed:meshHeading | pubmed-meshheading:8986743-... | lld:pubmed |
| pubmed-article:8986743 | pubmed:meshHeading | pubmed-meshheading:8986743-... | lld:pubmed |
| pubmed-article:8986743 | pubmed:meshHeading | pubmed-meshheading:8986743-... | lld:pubmed |
| pubmed-article:8986743 | pubmed:meshHeading | pubmed-meshheading:8986743-... | lld:pubmed |
| pubmed-article:8986743 | pubmed:meshHeading | pubmed-meshheading:8986743-... | lld:pubmed |
| pubmed-article:8986743 | pubmed:meshHeading | pubmed-meshheading:8986743-... | lld:pubmed |
| pubmed-article:8986743 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:8986743 | pubmed:articleTitle | Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice. | lld:pubmed |
| pubmed-article:8986743 | pubmed:affiliation | Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA. | lld:pubmed |
| pubmed-article:8986743 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8986743 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:8986743 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8986743 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:19164 | entrezgene:pubmed | pubmed-article:8986743 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986743 | lld:pubmed |
