Linked Life Data

8985308

Source:http://linkedlifedata.com/resource/pubmed/id/8985308

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1997-1-30
pubmed:abstractText
Since the previous review on the role of opioids in the immune system, numerous investigative teams have contributed to the growing pool of information illustrating the tangible relationship between opioids and immune function, particularly as this association pertains to bacterial and viral pathogens. In addition, the recent cloning of both neural- and immune-derived opioid receptors will ultimately facilitate the identification of molecular events that are responsible for the immunomodulatory effects that are mediated by receptor ligation. Specifically, the administration of opioids in vivo can potentially affect the immune system either through direct interaction with receptors on the effector cells or indirectly, through the ligation of receptors found within the central nervous system. This indirect routing is hypothesized to involve secondary pathways including the hypothalamic pituitary adrenal (HPA) axis and the sympathetic nervous system ultimately resulting in immunomodulation. Consequently, a portion of this review addresses the recent data on leukocyte-derived opioid receptors and the potential immunoregulatory role relative to opiold receptors found within the central nervous system. In addition, recent observations on the effects of opioids and immunocompetence is reviewed from both a molecular and cellular perspective. Finally, the consequence of opioid exposure on the competence of the host immune system to microbial pathogens is summarized.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0037-9727
pubmed:author
pubmed:issnType
Print
pubmed:volume
213
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
248-57
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
The relevance of opioids and opioid receptors on immunocompetence and immune homeostasis.
pubmed:affiliation
Department of Microbiology, LSU Stanley S. Scott and Neuroscience Centers, LSU Medical Center, New Orleans, Louisiana 70112-1393, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Review