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rdf:type |
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|
lifeskim:mentions |
|
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pubmed:issue |
1
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pubmed:dateCreated |
1997-1-9
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pubmed:abstractText |
A MeOH extract of Swertia chirata found to inhibit the catalytic activity of topoisomerase I of Leishmania donovani was subjected to fractionation to yield three secoiridoid glycosides: amarogentin (1), amaroswerin (2), and sweroside (3). Amarogentin is a potent inhibitor of type I DNA topoisomerase from Leishmania and exerts its effect by interaction with the enzyme, preventing binary complex formation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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|
pubmed:month |
Jan
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pubmed:issn |
0163-3864
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
59
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
27-9
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:8984149-Animals,
pubmed-meshheading:8984149-DNA, Protozoan,
pubmed-meshheading:8984149-Enzyme Inhibitors,
pubmed-meshheading:8984149-Glucosides,
pubmed-meshheading:8984149-India,
pubmed-meshheading:8984149-Iridoids,
pubmed-meshheading:8984149-Leishmania donovani,
pubmed-meshheading:8984149-Magnetic Resonance Spectroscopy,
pubmed-meshheading:8984149-Plants, Medicinal,
pubmed-meshheading:8984149-Pyrans,
pubmed-meshheading:8984149-Topoisomerase I Inhibitors
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pubmed:year |
1996
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pubmed:articleTitle |
Amarogentin, a naturally occurring secoiridoid glycoside and a newly recognized inhibitor of topoisomerase I from Leishmania donovani.
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pubmed:affiliation |
Indian Institute of Chemical Biology, Calcutta, India.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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