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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1979-10-26
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pubmed:abstractText |
Metaplastic epithelial cells are often observed lining alveoli in bleomycin-induced pulmonary fibrosis. The hypothesis that these cellular changes are induced by the direct action of the drug on differentiating Type 2 cells is now examined in a sequential study to correlate the presence of 3H bleomycin in the lung with the pattern of injury and repair of the alveolar epithelium. A single intravenous dose or multiple small intraperitoneal doses induce focal necrosis of Type 1 epithelial cells followed by Type 2 cell regeneration. At the time of maximal deoxyribonucleic acid (DNA) synthesis in these cells, significant amounts of 3H bleomycin are demonstrable in the lung by scintillation counting; and in autoradiographs, the drug appears to concentrate in epithelial cells. Subsequently many abnormal Type 2 cells are seen. Some are binucleate, and others show nuclear disruption. The usual process of differentiation to Type 1 cells does not occur; instead, a variety of epithelial forms are found, including fetal-like tubular structures and ciliated and squamous metaplastic cells. The correlation of epithelial injury and repair with the direct demonstration of bleomycin in the lung indicates that Type 2 cells are susceptible to injury in the division and differentiation phases of the cell cycle and may then produce a variety of inappropriate alveolar lining cells.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/89815-1036675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/89815-4123792,
http://linkedlifedata.com/resource/pubmed/commentcorrection/89815-4139043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/89815-4141224,
http://linkedlifedata.com/resource/pubmed/commentcorrection/89815-4566990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/89815-4812806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/89815-4975612,
http://linkedlifedata.com/resource/pubmed/commentcorrection/89815-5021311,
http://linkedlifedata.com/resource/pubmed/commentcorrection/89815-5337399,
http://linkedlifedata.com/resource/pubmed/commentcorrection/89815-5476243,
http://linkedlifedata.com/resource/pubmed/commentcorrection/89815-57003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/89815-60170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/89815-60174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/89815-63965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/89815-66869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/89815-66980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/89815-68683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/89815-71149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/89815-830993,
http://linkedlifedata.com/resource/pubmed/commentcorrection/89815-923747
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0002-9440
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
96
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
531-44
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1979
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pubmed:articleTitle |
Bleomycin-induced injury and metaplasia of alveolar type 2 cells. Relationship of cellular responses to drug presence in the lung.
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pubmed:publicationType |
Journal Article
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