Linked Life Data

8981475

Source:http://linkedlifedata.com/resource/pubmed/id/8981475

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
15-17
pubmed:dateCreated
1997-4-1
pubmed:abstractText
To test specificity of the involvement of vagal afferents in the communication between the immune system and the brain, sham-operated and vagotomized mice were injected i.p., s.c. or i.v. with physiological saline or interleukin-1 beta (IL-1 beta [symbol: see text] 4 weeks after surgery. Vagotomy attenuated the decrease in social exploration induced by i.p. injection of 300 ng recombinant human IL-1 beta but had no effect when IL-1 beta was injected s.c. (300 ng) or i.v. (500 ng). Vagotomy also attenuated the depression in social investigation induced by i.p. injection of recombinant rat IL-1 beta (IL-1 beta, 1 microgram) but was without effect when 1 microgram IL-1 beta was injected i.v. These results confirm the role of vagal afferent nerves in the transmission of an immune message from the periphery to the brain and show that the vagus nerve only conveys information concerning cytokines injected into the abdominal cavity.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0959-4965
pubmed:author
pubmed:issnType
Print
pubmed:day
4
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2823-7
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Vagotomy blocks behavioural effects of interleukin-1 injected via the intraperitoneal route but not via other systemic routes.
pubmed:affiliation
INRA-INSERM U394, Domaine de Carreire, Bordeaux, France.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't