Linked Life Data

8981455

Source:http://linkedlifedata.com/resource/pubmed/id/8981455

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
15-17
pubmed:dateCreated
1997-4-1
pubmed:abstractText
Mice deficient for the fyn gene were examined for their susceptibility to seizures induced by various convulsive drugs, including pentylenetetrazol, picrotoxin, bicuculline, kainic acid, N-methyl-D-aspartate (NMDA) and strychnine. Homozygous mutant (fynz/fynz) mice were significantly more likely to show myoclonic convulsions than were heterozygous mutants (+/fynz), when pentylenetetrazol, picrotoxin, bicuculline, kainic acid and NMDA were administered. On the other hand, no difference in seizure susceptibility was found between homozygous and heterozygous mutants when strychnine was administered. These results provide evidence of abnormal susceptibility to seizures induced by anti-GABAergic agents and agonists for central excitatory amino acids in Fyn-deficient mice.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0959-4965
pubmed:author
pubmed:issnType
Print
pubmed:day
4
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2723-6
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Susceptibility to drug-induced seizures of Fyn tyrosine kinase-deficient mice.
pubmed:affiliation
Department of Psychology, Faculty of Letters, University of Tokyo, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't