rdf:type |
|
lifeskim:mentions |
umls-concept:C0003865,
umls-concept:C0006644,
umls-concept:C0010583,
umls-concept:C0026809,
umls-concept:C0034693,
umls-concept:C0205195,
umls-concept:C0536760,
umls-concept:C0971858,
umls-concept:C1527144,
umls-concept:C1527148,
umls-concept:C1527240
|
pubmed:issue |
7
|
pubmed:dateCreated |
1997-4-1
|
pubmed:abstractText |
1. Cofpropamine (Cofa), a caffeine derivative that inhibits polyadenoribosylation, enhances the therapeutic effect of cyclophosphamide (CPA) in two animal models of arthritis. 2. The development of adjuvant arthritis of rats is reduced by treatment with 2 x 50 mg/kg IP CPA and 2 x 50 mg/kg IP Cofa. 3. The development of collagen arthritis in mice is prevented by treatment with 12.5 mg/kg IP CPA and 150 mg/kg IP Cofa three times per week.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
0306-3623
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
27
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1215-8
|
pubmed:dateRevised |
2003-11-14
|
pubmed:meshHeading |
pubmed-meshheading:8981070-Alkylating Agents,
pubmed-meshheading:8981070-Animals,
pubmed-meshheading:8981070-Arthritis, Experimental,
pubmed-meshheading:8981070-Body Weight,
pubmed-meshheading:8981070-Caffeine,
pubmed-meshheading:8981070-Collagen,
pubmed-meshheading:8981070-Cyclophosphamide,
pubmed-meshheading:8981070-Drug Synergism,
pubmed-meshheading:8981070-Enzyme Inhibitors,
pubmed-meshheading:8981070-Foot,
pubmed-meshheading:8981070-Joints,
pubmed-meshheading:8981070-Male,
pubmed-meshheading:8981070-Mice,
pubmed-meshheading:8981070-Mice, Inbred DBA,
pubmed-meshheading:8981070-Poly(ADP-ribose) Polymerases,
pubmed-meshheading:8981070-Rats,
pubmed-meshheading:8981070-Rats, Wistar
|
pubmed:year |
1996
|
pubmed:articleTitle |
The therapeutic effect of a combination of cofpropamine, a caffeine derivative, and cyclophosphamide on the development of adjuvant arthritis of rats and collagen arthritis of mice.
|
pubmed:affiliation |
Deutsches Rheumaforschungszentrum Berlin, Germany.
|
pubmed:publicationType |
Journal Article
|