Linked Life Data

8980992

Source:http://linkedlifedata.com/resource/pubmed/id/8980992

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1997-3-20
pubmed:abstractText
Retinoic acids (RA) regulate growth and differentiation of normal epithelial tissue. They have been employed in anticancer treatment and showed positive effects in hematopoetic and various epithelial tumors. Experimental data with follicular thyroid tumor cells showed strong evidence of induction of differentiated cell function and antiproliferative effects. Based on these data a consecutive series of 10 patients with advanced thyroid carcinoma were treated with 13-cis-retinoic acid (Roaccutan) 1.5 mg/kg body weight for six weeks. Follow-up demonstrated renewed uptake of radioiodine in 4 of 10 patients allowing performance of further radioiodine therapy. Reduction in tumor size due to antiproliferative effects of RA could not yet be verified.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0947-7349
pubmed:author
pubmed:issnType
Print
pubmed:volume
104 Suppl 4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
13-5
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Redifferentiation therapy of differentiated thyroid carcinoma with retinoic acid: basics and first clinical results.
pubmed:affiliation
Klinik für Allgemeine und Unfallchirurgie, Heinrich-Heine-University, Düsseldorf, Germany.
pubmed:publicationType
Journal Article