Linked Life Data

8980612

Source:http://linkedlifedata.com/resource/pubmed/id/8980612

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1997-1-23
pubmed:abstractText
Most non-Hodgkin's lymphomas (NHLs) express a number of different adhesion receptors. A large body of evidence indicates that these adhesion receptors not only regulate normal lymphocyte trafficking but also play a pivotal role in the dissemination of NHL. Thus, cutaneous lymphocyte antigen, alpha 4 beta 7, alpha E beta 7, and L-selectin, which mediate the tissue-specific positioning of normal lymphocytes in the skin, mucosa, epithelium and lymph nodes, respectively, are selectively expressed on lymphomas localized at these sites. Furthermore, expression of CD44, a family of adhesion receptors with pleiotropic effects on tumor behavior, is related to lymphoma aggressiveness and dissemination. Taken together, these findings offer a framework for the understanding of tumor dissemination in NHL. In view of the similarities between lymphocyte behavior and the metastatic behavior of solid tumors, these insights might contribute to the understanding of the basic mechanisms underlying tumor metastasis in non-lymphoid tumors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0001-5792
pubmed:author
pubmed:issnType
Print
pubmed:volume
97
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
73-80
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Adhesion molecules in the dissemination of non-Hodgkin's lymphomas.
pubmed:affiliation
Department of Pathology, Academic Medical Center, University of Amsterdam, The Netherlands.
pubmed:publicationType
Journal Article, Review