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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1997-1-30
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pubmed:abstractText |
Loss of heterozygosity (LOH) in chromosome 6 in human squamous cervical carcinomas was analyzed in the long and short arms of the chromosome using 3 pairs of primers each. In all cases, normal adjacent tissue was used as control. Among 51 cases analyzed, we identified LOH or microsatellite instability in 23% using primer D6S291 (located at position 6p21.3) and in 11% using primers D6S308 (6q16.3-6q27) and D6S270 (6q22.3-6q23.2). On the contrary, no significant LOH or genomic instabilities were detected with primers D6S306 (6p22.3-6p21.2), D6S299 (6p22.3-6p21.3) and D6S287 (6q21-6q23.3). Our results thus suggest the existence of instable loci at 3 regions of chromosome 6. Whether these loci contain putative tumor-suppressor genes or genes involved in cell cycle control remains unknown.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0020-7136
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pubmed:author |
pubmed-author:AlonsoAA,
pubmed-author:GritzkoTT,
pubmed-author:KisseljovFF,
pubmed-author:KomissarovaEE,
pubmed-author:KozachenkoVV,
pubmed-author:MazurenkoNN,
pubmed-author:NetchushkinMM,
pubmed-author:PetrovSS,
pubmed-author:SamoylovaEE,
pubmed-author:SemionovaLL,
pubmed-author:SmirnovAA,
pubmed-author:ZourbitskayaVV
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
69
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
484-7
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pubmed:dateRevised |
2007-7-24
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pubmed:meshHeading |
pubmed-meshheading:8980252-Adenocarcinoma,
pubmed-meshheading:8980252-Carcinoma, Squamous Cell,
pubmed-meshheading:8980252-Carcinoma in Situ,
pubmed-meshheading:8980252-Chromosomes, Human, Pair 6,
pubmed-meshheading:8980252-DNA, Neoplasm,
pubmed-meshheading:8980252-Female,
pubmed-meshheading:8980252-Heterozygote,
pubmed-meshheading:8980252-Humans,
pubmed-meshheading:8980252-Microsatellite Repeats,
pubmed-meshheading:8980252-Papillomaviridae,
pubmed-meshheading:8980252-Papillomavirus Infections,
pubmed-meshheading:8980252-Polymerase Chain Reaction,
pubmed-meshheading:8980252-Tumor Virus Infections,
pubmed-meshheading:8980252-Uterine Cervical Neoplasms
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pubmed:year |
1996
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pubmed:articleTitle |
Instability of chromosome 6 microsatellite repeats in human cervical tumors carrying papillomavirus sequences.
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pubmed:affiliation |
Department of Viral Molecular Biology, Kazan Cancer Research Center, Moscow, Russia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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