Linked Life Data

8979114

Source:http://linkedlifedata.com/resource/pubmed/id/8979114

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1997-4-29
pubmed:abstractText
Platelets play a key role in arterial thrombosis. Inhibition of platelet function forms an essential part of anti-thrombotic therapy. Although aspirin is a cost-effective drug which offers considerable scope in the prevention of arterial thrombosis, it only inhibits part of the platelet activation process. Much recent progress has concerned the inhibition of surface receptors of platelets. Ticlopidine and clopidogrel specifically interfere with the ADP-induced activation pathway. Inhibitors of GP IIb-IIIa complexes, including c7E3, block the final step of the platelet aggregation process as used by all physiologic agonists and are proving powerful therapeutic agents. This review looks at these and future advances in the construction of therapeutic strategies aimed at combatting arterial thrombosis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0301-0147
pubmed:author
pubmed:issnType
Print
pubmed:volume
26 Suppl 4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
78-88
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
New thoughts on strategies for modulating platelet function through the inhibition of surface receptors.
pubmed:affiliation
UMR 5533 CNRS, Hôpital Cardiologique, Pessac, France.
pubmed:publicationType
Journal Article, Review