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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1997-1-16
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pubmed:abstractText |
We have investigated the antitumor effect of murine colon carcinoma cells developed to produce cytokines. Retrovirally transduced cells were inoculated into syngeneic mice, and their survivals were examined. Inoculation of interleukin-4 (IL-4)- or granulocyte macrophage-colony stimulating factor (GM-CSF)-producing cells alone did not affect the survival of the mice. In the tumors derived from an admixture of IL-4 and GM-CSF producers, however, regression developed spontaneously, and prolonged survival of the challenged mice was consequently observed. Histological examination revealed predominant infiltration of neutrophils around the tumor of a mixed population of IL-4 and GM-CSF producers.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0030-2414
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pubmed:author |
pubmed-author:AsanoTT,
pubmed-author:GunjiYY,
pubmed-author:IsonoKK,
pubmed-author:KageyamaHH,
pubmed-author:KondoFF,
pubmed-author:MatsubaraHH,
pubmed-author:NakajimaKK,
pubmed-author:NakamuraYY,
pubmed-author:OchiaiTT,
pubmed-author:SakiyamaSS,
pubmed-author:ShimadaHH,
pubmed-author:SugayaMM,
pubmed-author:SuzukiTT,
pubmed-author:TagawaMM,
pubmed-author:TakenagaKK
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pubmed:issnType |
Print
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
69-73
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8978596-Animals,
pubmed-meshheading:8978596-Colonic Neoplasms,
pubmed-meshheading:8978596-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:8978596-Female,
pubmed-meshheading:8978596-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:8978596-Genetic Vectors,
pubmed-meshheading:8978596-Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:8978596-Interleukin-4,
pubmed-meshheading:8978596-Mice,
pubmed-meshheading:8978596-Mice, Inbred BALB C,
pubmed-meshheading:8978596-Retroviridae,
pubmed-meshheading:8978596-Survival Analysis,
pubmed-meshheading:8978596-Tumor Cells, Cultured
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pubmed:articleTitle |
Antitumor effect of murine colon carcinoma cells retrovirally transduced with interleukin-4 and granulocyte macrophage-colony stimulating factor genes.
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pubmed:affiliation |
Department of Surgery (II), Chiba University School of Medicine, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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