Statements in which the resource exists as a subject.
PredicateObject
rdf:type
pubmed:issue
6
pubmed:dateCreated
1997-1-24
pubmed:abstractText
Chronopharmacology studies the influence of time of administration of drugs. Numerous studies have report on the influence of time of administration on acute toxicity of drugs. Qualitative and quantitative responses of the organism to drugs have been described in different areas such as anaesthesiology, cardiology, oncology, endocrinology, gastroenterology, obstetrics, neurology, pneumology, psychiatry, rheumatology... in animals and in men. Underlying mechanisms of such variations involve temporal variations of the mode of action of the drug i.e. at the receptor level or temporal modifications of the kinetics of the drug. Absorption, distribution and drug protein binding, metabolism and elimination vary according to the moment of administration of the drug. Chronotherapy consists on the choice of the moment of administration of a drug in order to minimise its side effects and/or to emphasize its therapeutic effects.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0369-8114
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
547-54
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
[Chronopharmacology].
pubmed:affiliation
Laboratoire de Pharmacologie Médicale et Clinique, Faculté de Médecine de Marseille, France.
pubmed:publicationType
Journal Article, English Abstract, Review