Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1997-1-23
|
| pubmed:abstractText |
There are now six recognized neuropeptide Y (NPY) receptor subtypes (Y1-Y4 and two recently cloned distinct receptors labeled Y5), of which Y1 and one of the Y5's have been suggested could mediate the effect of NPY on feeding. The fragments NPY(2-36) and NPY(3-36), which bind Y1 only poorly, were injected intracerebroventricularly (icv) and found to have similar dose-response relationships to NPY in the stimulation of feeding. However NPY (13-36), which stimulates both Y2 and Y5, caused no increase in food intake, even at high doses. Maximal stimulation with the classical Y1 agonist [Pro34]-NPY produced only 50% of the maximum effect of NPY itself despite fully inhibiting adenylyl cyclase activity in vitro in a Y1 system. The novel fragment [Pro34]-NPY(3-36) is as effective at stimulating food intake as the classical Y1 analogue [Pro34]-NPY but bound to the Y1 receptor with only 1/20th of the affinity of NPY and failed to inhibit adenylyl cyclase through this receptor. [Pro34]-NPY(3-36) is therefore a relatively appetite-selective ligand. Coadministration of high dose NPY(13-36) and [Pro34]NPY did not enhance feeding compared with [Pro34]-NPY alone. In addition, the NPY Y1 receptor antagonist BIBP-3226, which does not bind Y2, Y4, or Y5 receptors, significantly reduced NPY induced feeding. These results indicate that the feeding effect of icv NPY involves a novel receptor and that it is functionally distinct from the recognized receptor subtypes.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0013-7227
|
| pubmed:author |
pubmed-author:BloomC ICI,
pubmed-author:BloomS RSR,
pubmed-author:CallinanWW,
pubmed-author:ChoiS JSJ,
pubmed-author:EdwardsC MCM,
pubmed-author:GhateiM AMA,
pubmed-author:GunnII,
pubmed-author:HaddoOO,
pubmed-author:HeathM MMM,
pubmed-author:HowardJ KJK,
pubmed-author:LyJ CJC,
pubmed-author:MeeranKK,
pubmed-author:MorganD GDG,
pubmed-author:O'SheaDD,
pubmed-author:SmallC JCJ,
pubmed-author:SmithD MDM,
pubmed-author:TaylorG MGM,
pubmed-author:TurtonM DMD
|
| pubmed:issnType |
Print
|
| pubmed:volume |
138
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
196-202
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8977404-Adenylate Cyclase,
pubmed-meshheading:8977404-Animals,
pubmed-meshheading:8977404-Cells, Cultured,
pubmed-meshheading:8977404-Eating,
pubmed-meshheading:8977404-Male,
pubmed-meshheading:8977404-Neuropeptide Y,
pubmed-meshheading:8977404-Rats,
pubmed-meshheading:8977404-Rats, Wistar,
pubmed-meshheading:8977404-Receptors, Neuropeptide Y
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Neuropeptide Y induced feeding in the rat is mediated by a novel receptor.
|
| pubmed:affiliation |
Department of Medicine, Hammersmith Hospital, Royal Postgraduate Medical School, London, United Kingdom.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|