| pubmed-article:8977288 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8977288 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:8977288 | lifeskim:mentions | umls-concept:C0439793 | lld:lifeskim |
| pubmed-article:8977288 | lifeskim:mentions | umls-concept:C0971858 | lld:lifeskim |
| pubmed-article:8977288 | lifeskim:mentions | umls-concept:C0392756 | lld:lifeskim |
| pubmed-article:8977288 | lifeskim:mentions | umls-concept:C0021149 | lld:lifeskim |
| pubmed-article:8977288 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:8977288 | pubmed:dateCreated | 1997-2-4 | lld:pubmed |
| pubmed-article:8977288 | pubmed:abstractText | Collagen-induced arthritis (CIA) is an animal model for rheumatoid arthritis. The disease is elicited by immunization of genetically susceptible DBA/1 mice with type II collagen, resulting in a debilitating arthritis characterized by inflammation and involvement of multiple joints. We investigated the role of endogenous interleukin (IL)-12 in the pathogenesis of this disease by undertaking an analysis of IL-12-deficient mice on the DBA/1 genetic background after immunization with type II collagen. Both the incidence and severity of disease were significantly reduced in mice unable to produce biologically active IL-12. Concomitant decreases were observed in serum levels of pathogenic, collagen-specific IgG2a antibodies and collagen-induced secretion of interferon-gamma by immune splenocytes in vitro, consistent with an impaired T helper-1 response. There were, however, a few animals which developed severe disease in a single paw in spite of this highly diminished Th1 response. Taken together, these results demonstrate an important role for IL-12 in the pathogenesis of CIA, although it is not absolutely required for disease development. | lld:pubmed |
| pubmed-article:8977288 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8977288 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8977288 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8977288 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8977288 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8977288 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8977288 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8977288 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8977288 | pubmed:issn | 0014-2980 | lld:pubmed |
| pubmed-article:8977288 | pubmed:author | pubmed-author:GatelyM KMK | lld:pubmed |
| pubmed-article:8977288 | pubmed:author | pubmed-author:ArpL HLH | lld:pubmed |
| pubmed-article:8977288 | pubmed:author | pubmed-author:McIntyreK WKW | lld:pubmed |
| pubmed-article:8977288 | pubmed:author | pubmed-author:MagramJJ | lld:pubmed |
| pubmed-article:8977288 | pubmed:author | pubmed-author:HallL BLB | lld:pubmed |
| pubmed-article:8977288 | pubmed:author | pubmed-author:ConnaughtonS... | lld:pubmed |
| pubmed-article:8977288 | pubmed:author | pubmed-author:ShusterD JDJ | lld:pubmed |
| pubmed-article:8977288 | pubmed:author | pubmed-author:WarrierR RRR | lld:pubmed |
| pubmed-article:8977288 | pubmed:author | pubmed-author:GilloolyK MKM | lld:pubmed |
| pubmed-article:8977288 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8977288 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:8977288 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8977288 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8977288 | pubmed:pagination | 2933-8 | lld:pubmed |
| pubmed-article:8977288 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:8977288 | pubmed:meshHeading | pubmed-meshheading:8977288-... | lld:pubmed |
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| pubmed-article:8977288 | pubmed:meshHeading | pubmed-meshheading:8977288-... | lld:pubmed |
| pubmed-article:8977288 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8977288 | pubmed:articleTitle | Reduced incidence and severity of collagen-induced arthritis in interleukin-12-deficient mice. | lld:pubmed |
| pubmed-article:8977288 | pubmed:affiliation | Department of Inflammation/Autoimmune Diseases, Hoffmann-La Roche Inc., Nutley, NJ 07110, USA. | lld:pubmed |
| pubmed-article:8977288 | pubmed:publicationType | Journal Article | lld:pubmed |
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