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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
|
| pubmed:dateCreated |
1997-2-4
|
| pubmed:abstractText |
The role of Fas in the homeostatic regulation of CD8+ T cells after antigen challenge was analyzed in the murine model of lymphocytic choriomeningitis virus (LCMV) infection. Mice homozygous for the lpr mutation and carrying T cell receptor (TCR) alphabeta transgenes specific for the LCMV glycoprotein peptide aa 33-41 in the context of H-2Db were used. Five main results emerged: first, development of lymphadenopathy and of CD4- CD8- double-negative B220+ T cells in lpr mice was not inhibited by the alphabeta TCR transgenes; second, tolerance induction and peripheral deletion of CD8+ T cells induced by LCMV glycoprotein peptide injection was independent of Fas expression; third, clonal down-regulation of Fas-deficient TCR-transgenic CD8+ T cells after acute LCM virus infection was identical to the decline of transgenic T cells expressing Fas; fourth, in vivo activated CD8+ effector T cells from TCR transgenic and TCR-lpr/lpr mice were equally susceptible to activation-induced cell death in vitro; and fifth, transgenic effector T cells from lpr/lpr mice were cleared in the declining phase of the immune response in vivo without giving rise to CD4- CD8- double-negative T cells. Taken together, these data suggest that the homeostatic regulation of CD8+ T cells after antigen challenge in vivo is regulated by mechanisms that do not require Fas.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0014-2980
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
26
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2903-10
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8977284-Animals,
pubmed-meshheading:8977284-Antigens, CD95,
pubmed-meshheading:8977284-Antigens, Viral,
pubmed-meshheading:8977284-CD8-Positive T-Lymphocytes,
pubmed-meshheading:8977284-Cell Death,
pubmed-meshheading:8977284-Clonal Deletion,
pubmed-meshheading:8977284-Down-Regulation,
pubmed-meshheading:8977284-Female,
pubmed-meshheading:8977284-Homeostasis,
pubmed-meshheading:8977284-Immune Tolerance,
pubmed-meshheading:8977284-Lymphocyte Activation,
pubmed-meshheading:8977284-Lymphocytic Choriomeningitis,
pubmed-meshheading:8977284-Lymphocytic choriomeningitis virus,
pubmed-meshheading:8977284-Male,
pubmed-meshheading:8977284-Mice,
pubmed-meshheading:8977284-Mice, Inbred C57BL,
pubmed-meshheading:8977284-Mice, Mutant Strains,
pubmed-meshheading:8977284-Mice, Transgenic,
pubmed-meshheading:8977284-Peptides
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Homeostatic regulation of CD8+ T cells after antigen challenge in the absence of Fas (CD95).
|
| pubmed:affiliation |
Institute for Medical Microbiology and Hygiene, Department of Immunology, University of Freiburg, Germany.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|