Linked Life Data

8976541

Source:http://linkedlifedata.com/resource/pubmed/id/8976541

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1997-3-28
pubmed:abstractText
Five rats were trained to respond for 10% sucrose and 10% sucrose/0.006% quinine in an operant procedure. Both solutions were concurrently available on independent, variable-interval 5-s schedules of reinforcement. Rats reliably responded for both solutions throughout the sessions and made approximately 68% of their total daily responses for the sucrose solution. When injected prior to the sessions with 4 mg/kg of chlordiazepoxide, rats selectively increased quinine responding; injections of the benzodiazepine inverse agonist Ro 15-4513 (9 mg/kg) led to decreased quinine responding. The effects of both chlordiazepoxide and Ro 15-4513 were reversed by the benzodiazepine antagonist flumazenil. Presession injections of flumazenil, muscimol, baclofen, or picrotoxin all resulted in no changes in responding, or a decrease in responding for both solutions. These results are discussed in terms of a bidirectional modulation of sweet-bitter taste preference by drugs acting on the benzodiazepine receptor. Moreover, the data from these experiments suggest that any changes in the oral consumption of alcohol following administration of benzodiazepine drugs must be examined in light of their effects on taste palatability.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0031-9384
pubmed:author
pubmed:issnType
Print
pubmed:volume
61
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
119-26
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Bidirectional modulation of sweet and bitter taste by chlordiazepoxide and Ro 15-4513: lack of effect with GABA drugs.
pubmed:affiliation
Department of Psychology, Harvard University, Cambridge, MA 02138, USA. petry@psychiatry.uche.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't