Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1997-1-30
pubmed:abstractText
The function of the minor subset of T lymphocytes bearing the gamma delta T cell antigen receptor is uncertain. Although some gamma delta T cells react to microbial products, responsiveness has only rarely been demonstrated toward a bacterial antigen from a naturally occurring human infection. Synovial fluid lymphocytes from patients with Lyme arthritis contain a large proportion of gamma delta cells that proliferate in response to the causative spirochete, Borrelia burgdorferi. Furthermore, synovial gamma delta T cell clones express elevated and sustained levels of the ligand for Fas (APO-1, CD95) compared to alpha beta T cells, and induce apoptosis of Fashigh CD4+ synovial lymphocytes. The findings suggest that gamma delta T cells contribute to defense in human infections, as well as manifest an immunoregulatory function at inflammatory sites by a Fas-dependent process.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8976167-1386870, http://linkedlifedata.com/resource/pubmed/commentcorrection/8976167-1400587, http://linkedlifedata.com/resource/pubmed/commentcorrection/8976167-1695022, http://linkedlifedata.com/resource/pubmed/commentcorrection/8976167-1831490, http://linkedlifedata.com/resource/pubmed/commentcorrection/8976167-2145388, http://linkedlifedata.com/resource/pubmed/commentcorrection/8976167-2185330, http://linkedlifedata.com/resource/pubmed/commentcorrection/8976167-2377230, http://linkedlifedata.com/resource/pubmed/commentcorrection/8976167-2471938, http://linkedlifedata.com/resource/pubmed/commentcorrection/8976167-2473405, http://linkedlifedata.com/resource/pubmed/commentcorrection/8976167-2524009, http://linkedlifedata.com/resource/pubmed/commentcorrection/8976167-2524098, http://linkedlifedata.com/resource/pubmed/commentcorrection/8976167-2524273, http://linkedlifedata.com/resource/pubmed/commentcorrection/8976167-2526925, http://linkedlifedata.com/resource/pubmed/commentcorrection/8976167-2527159, http://linkedlifedata.com/resource/pubmed/commentcorrection/8976167-2541219, http://linkedlifedata.com/resource/pubmed/commentcorrection/8976167-2564416, http://linkedlifedata.com/resource/pubmed/commentcorrection/8976167-2968521, http://linkedlifedata.com/resource/pubmed/commentcorrection/8976167-2978114, http://linkedlifedata.com/resource/pubmed/commentcorrection/8976167-7502042, http://linkedlifedata.com/resource/pubmed/commentcorrection/8976167-7504062, http://linkedlifedata.com/resource/pubmed/commentcorrection/8976167-7518614, http://linkedlifedata.com/resource/pubmed/commentcorrection/8976167-7520535, http://linkedlifedata.com/resource/pubmed/commentcorrection/8976167-7532432, http://linkedlifedata.com/resource/pubmed/commentcorrection/8976167-7532907, http://linkedlifedata.com/resource/pubmed/commentcorrection/8976167-7545118, http://linkedlifedata.com/resource/pubmed/commentcorrection/8976167-7566174, http://linkedlifedata.com/resource/pubmed/commentcorrection/8976167-7584140, http://linkedlifedata.com/resource/pubmed/commentcorrection/8976167-7636256, http://linkedlifedata.com/resource/pubmed/commentcorrection/8976167-7678113, http://linkedlifedata.com/resource/pubmed/commentcorrection/8976167-7706720, http://linkedlifedata.com/resource/pubmed/commentcorrection/8976167-7753173, http://linkedlifedata.com/resource/pubmed/commentcorrection/8976167-7905415, http://linkedlifedata.com/resource/pubmed/commentcorrection/8976167-7916481, http://linkedlifedata.com/resource/pubmed/commentcorrection/8976167-7980675, http://linkedlifedata.com/resource/pubmed/commentcorrection/8976167-8191583, http://linkedlifedata.com/resource/pubmed/commentcorrection/8976167-8245484, http://linkedlifedata.com/resource/pubmed/commentcorrection/8976167-8436183, http://linkedlifedata.com/resource/pubmed/commentcorrection/8976167-8476575, http://linkedlifedata.com/resource/pubmed/commentcorrection/8976167-8609166, http://linkedlifedata.com/resource/pubmed/commentcorrection/8976167-8627781, http://linkedlifedata.com/resource/pubmed/commentcorrection/8976167-8849370
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
184
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2109-17
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:8976167-Humans, pubmed-meshheading:8976167-Synovial Fluid, pubmed-meshheading:8976167-Arthritis, Infectious, pubmed-meshheading:8976167-Clone Cells, pubmed-meshheading:8976167-Lymphocyte Activation, pubmed-meshheading:8976167-T-Lymphocyte Subsets, pubmed-meshheading:8976167-Apoptosis, pubmed-meshheading:8976167-Receptors, Antigen, T-Cell, gamma-delta, pubmed-meshheading:8976167-Flow Cytometry, pubmed-meshheading:8976167-Immunophenotyping, pubmed-meshheading:8976167-DNA Primers, pubmed-meshheading:8976167-Lyme Disease, pubmed-meshheading:8976167-Borrelia burgdorferi Group, pubmed-meshheading:8976167-CD4-Positive T-Lymphocytes, pubmed-meshheading:8976167-Polymerase Chain Reaction, pubmed-meshheading:8976167-CD8-Positive T-Lymphocytes, pubmed-meshheading:8976167-Antigens, CD95
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