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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1997-3-5
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pubmed:databankReference |
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pubmed:abstractText |
GATA factors constitute a family of transcriptional regulatory proteins expressed with distinct developmental and tissue-specific profiles and thought to regulate cell-restricted programs of gene expression. Here we describe the molecular cloning, chromosomal location, and transcription of the human GATA-6 gene. The GATA-6 cDNA encodes a predicted 449-amino-acid protein, which is highly conserved among vertebrates, and includes the two adjacent zinc-finger/basic domains characteristic of the GATA factor family. GATA-6 maps to human chromosome 18q11.1-q11.2 by fluorescence in situ hybridization. The gene is transcribed in a pattern overlapping that of GATA-4. Transcripts for both of these genes are prominent in heart, pancreas, and ovary, but only GATA-6 mRNA is found in lung and liver. GATA-6 transcripts are also detected in cultures of human and rat vascular smooth muscle cells (VSMCs). In VSMCs, GATA-6 transcripts are down- regulated when quiescent cultures are stimulated to proliferate in response to mitogen activation. These data demonstrate that GATA-6 is subject to both tissue-specific and mitogen-responsive regulatory signals. GATA-6 is a prime candidate for a gene that might regulate the differentiative state of VSMCs.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0888-7543
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
38
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
283-90
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8975704-Amino Acid Sequence,
pubmed-meshheading:8975704-Animals,
pubmed-meshheading:8975704-Base Sequence,
pubmed-meshheading:8975704-Cattle,
pubmed-meshheading:8975704-Cells, Cultured,
pubmed-meshheading:8975704-Chromosome Mapping,
pubmed-meshheading:8975704-Chromosomes, Human, Pair 18,
pubmed-meshheading:8975704-DNA-Binding Proteins,
pubmed-meshheading:8975704-Fetal Heart,
pubmed-meshheading:8975704-GATA6 Transcription Factor,
pubmed-meshheading:8975704-Gene Expression Regulation,
pubmed-meshheading:8975704-Genes,
pubmed-meshheading:8975704-Humans,
pubmed-meshheading:8975704-In Situ Hybridization, Fluorescence,
pubmed-meshheading:8975704-Male,
pubmed-meshheading:8975704-Mitogens,
pubmed-meshheading:8975704-Molecular Sequence Data,
pubmed-meshheading:8975704-Muscle, Smooth, Vascular,
pubmed-meshheading:8975704-Muscle Proteins,
pubmed-meshheading:8975704-Organ Specificity,
pubmed-meshheading:8975704-RNA, Messenger,
pubmed-meshheading:8975704-Rats,
pubmed-meshheading:8975704-Rats, Sprague-Dawley,
pubmed-meshheading:8975704-Transcription Factors,
pubmed-meshheading:8975704-Trinucleotide Repeats,
pubmed-meshheading:8975704-Zinc Fingers
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pubmed:year |
1996
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pubmed:articleTitle |
The human GATA-6 gene: structure, chromosomal location, and regulation of expression by tissue-specific and mitogen-responsive signals.
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pubmed:affiliation |
Division of Cardiovascular Research, St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA. kwalsh@opal.tufts.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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