rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1997-3-5
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pubmed:databankReference |
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pubmed:abstractText |
Monitoring of loss of heterozygosity in human tumors has suggested that the 22q12 region may contain another tumor suppressor gene(s) in addition to the NF2 gene. The genomic sequencing of a 40-kb region bounded by the EWS and BAM22 genes and containing a CpG-rich region has identified two new genes in the q12 region of chromosome 22. One of them, GAR22, is closely related to mouse Gas2, a gene isolated as being negatively regulated by serum and growth factors and exhibiting a high expression in growth arrested mouse fibroblasts. The other, RRP22, belongs to the Ras superfamily, in which it defines a new subgroup. Its expression appears to be strictly limited to the central nervous system. Growth-arrest-specific and Ras-related genes are likely candidates to be involved in tumorigenic processes. Although no mutation was observed in a small set of meningiomas and schwannomas, alteration of these new genes should now be searched in other tumors with frequent allelic losses on chromosome 22 not associated with NF2 mutation.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/GAS2L1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Gas2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Microfilament Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/ras Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0888-7543
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
38
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
247-54
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pubmed:dateRevised |
2007-5-10
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pubmed:meshHeading |
pubmed-meshheading:8975699-Amino Acid Sequence,
pubmed-meshheading:8975699-Animals,
pubmed-meshheading:8975699-Base Sequence,
pubmed-meshheading:8975699-Blotting, Northern,
pubmed-meshheading:8975699-Brain,
pubmed-meshheading:8975699-Chromosomes, Human, Pair 22,
pubmed-meshheading:8975699-CpG Islands,
pubmed-meshheading:8975699-DNA, Neoplasm,
pubmed-meshheading:8975699-Fetus,
pubmed-meshheading:8975699-Gene Deletion,
pubmed-meshheading:8975699-Genes,
pubmed-meshheading:8975699-Genes, Neurofibromatosis 2,
pubmed-meshheading:8975699-Genes, ras,
pubmed-meshheading:8975699-Heterozygote,
pubmed-meshheading:8975699-Humans,
pubmed-meshheading:8975699-Meningeal Neoplasms,
pubmed-meshheading:8975699-Meningioma,
pubmed-meshheading:8975699-Mice,
pubmed-meshheading:8975699-Microfilament Proteins,
pubmed-meshheading:8975699-Molecular Sequence Data,
pubmed-meshheading:8975699-Multigene Family,
pubmed-meshheading:8975699-Nerve Tissue Proteins,
pubmed-meshheading:8975699-Neurilemmoma,
pubmed-meshheading:8975699-Polymerase Chain Reaction,
pubmed-meshheading:8975699-Proteins,
pubmed-meshheading:8975699-RNA, Messenger,
pubmed-meshheading:8975699-RNA, Neoplasm,
pubmed-meshheading:8975699-Sequence Alignment,
pubmed-meshheading:8975699-Sequence Homology, Amino Acid,
pubmed-meshheading:8975699-ras Proteins
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pubmed:year |
1996
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pubmed:articleTitle |
Identification of new members of the Gas2 and Ras families in the 22q12 chromosome region.
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pubmed:affiliation |
INSERM U434 Génétique des Tumeurs, Institut Curie, Section de Recherche, Paris, France. Jessica.Zucman-rossi@curie.fr
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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