| pubmed-article:8974994 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8974994 | lifeskim:mentions | umls-concept:C0029207 | lld:lifeskim |
| pubmed-article:8974994 | lifeskim:mentions | umls-concept:C0022889 | lld:lifeskim |
| pubmed-article:8974994 | lifeskim:mentions | umls-concept:C1136024 | lld:lifeskim |
| pubmed-article:8974994 | lifeskim:mentions | umls-concept:C0006732 | lld:lifeskim |
| pubmed-article:8974994 | lifeskim:mentions | umls-concept:C0205427 | lld:lifeskim |
| pubmed-article:8974994 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:8974994 | pubmed:dateCreated | 1996-12-30 | lld:pubmed |
| pubmed-article:8974994 | pubmed:abstractText | In a previous paper (Thalmann et al., 1993) we reported that the amino acid sequence of OCP2, a low molecular weight acidic protein present in extremely high concentrations in the organ of Corti and absent in the basilar papilla, exhibits a rudimentary EF-hand--a potential calcium-binding domain. The present study was undertaken to determine whether OCP2 binds 45-calcium under non-denaturing conditions following separation by isoelectric focusing and transblotting. The same criterion was used to determine whether the EF-hands of several other calcium-binding proteins (CBP) are functional in organ of Corti and basilar papilla. OCP2 exhibited no 45-calcium binding. Calmodulin, present in the organ of Corti in extremely high concentrations and lower in basilar papilla, showed strong 45-calcium binding in both structures. While calbindin represents a major protein in basilar papilla and binds 45-calcium, this protein is a minor component in the organ of Corti; whether it binds 45-calcium remains to be decided. By extending the pI range in the acidic region of isoelectric focusing, a 15 kDa, highly acidic (pI approximately 3.1) protein was revealed that constitutes a major protein in the organ of Corti; the protein was not detectable in the basilar papilla, spiral ligament/stria vascularis complex and numerous other organs tested. It remains to be resolved whether this protein represents an isoform of parvalbumin or a novel CBP. The differential make-up of CBPs between the mammalian organ of Corti and the avian basilar papilla is discussed. | lld:pubmed |
| pubmed-article:8974994 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8974994 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8974994 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8974994 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8974994 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8974994 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8974994 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8974994 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8974994 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8974994 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8974994 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8974994 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8974994 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8974994 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:8974994 | pubmed:issn | 0378-5955 | lld:pubmed |
| pubmed-article:8974994 | pubmed:author | pubmed-author:ThalmannRR | lld:pubmed |
| pubmed-article:8974994 | pubmed:author | pubmed-author:ThalmannII | lld:pubmed |
| pubmed-article:8974994 | pubmed:author | pubmed-author:SenaritaMM | lld:pubmed |
| pubmed-article:8974994 | pubmed:author | pubmed-author:ShibasakiOO | lld:pubmed |
| pubmed-article:8974994 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8974994 | pubmed:volume | 90 | lld:pubmed |
| pubmed-article:8974994 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8974994 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8974994 | pubmed:pagination | 169-75 | lld:pubmed |
| pubmed-article:8974994 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:8974994 | pubmed:meshHeading | pubmed-meshheading:8974994-... | lld:pubmed |
| pubmed-article:8974994 | pubmed:meshHeading | pubmed-meshheading:8974994-... | lld:pubmed |
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| pubmed-article:8974994 | pubmed:meshHeading | pubmed-meshheading:8974994-... | lld:pubmed |
| pubmed-article:8974994 | pubmed:meshHeading | pubmed-meshheading:8974994-... | lld:pubmed |
| pubmed-article:8974994 | pubmed:meshHeading | pubmed-meshheading:8974994-... | lld:pubmed |
| pubmed-article:8974994 | pubmed:meshHeading | pubmed-meshheading:8974994-... | lld:pubmed |
| pubmed-article:8974994 | pubmed:meshHeading | pubmed-meshheading:8974994-... | lld:pubmed |
| pubmed-article:8974994 | pubmed:meshHeading | pubmed-meshheading:8974994-... | lld:pubmed |
| pubmed-article:8974994 | pubmed:meshHeading | pubmed-meshheading:8974994-... | lld:pubmed |
| pubmed-article:8974994 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:8974994 | pubmed:articleTitle | Calcium-binding proteins in organ of Corti and basilar papilla: CBP-15, an unidentified calcium-binding protein of the inner ear. | lld:pubmed |
| pubmed-article:8974994 | pubmed:affiliation | Department of Otolaryngology, Washington University, St. Louis MO 63110, USA. | lld:pubmed |
| pubmed-article:8974994 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8974994 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8974994 | lld:pubmed |
