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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1997-4-10
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pubmed:abstractText |
In this report we show that the mouse interferon (IFN)-gamma R1 and IFN-gamma R2 subunits expressed in hamster cells are capable of rendering the cells sensitive to mouse IFN-gamma as measured by induction of class I MHC antigens and the activation of the transcription factor Stat1 alpha. However, these cells showed no antiviral protection in response to IFN-gamma when challenged with vesicular stomatitis virus (VSV) but limited protection when challenged with encephalomyocarditis virus (EMCV). Furthermore, the cytoplasmic domains of the IFN-gamma R2 subunits, like the cytoplasmic domains of the IFN-gamma R1 chains, can be interchanged between species with no loss of biologic activity, demonstrating that the species-specific interaction of the IFN-gamma R1 and IFN-gamma R2 chains involves only the extracellular domains of the two proteins.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1079-9907
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1039-45
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8974007-Amino Acid Sequence,
pubmed-meshheading:8974007-Animals,
pubmed-meshheading:8974007-Antiviral Agents,
pubmed-meshheading:8974007-CHO Cells,
pubmed-meshheading:8974007-Cell Division,
pubmed-meshheading:8974007-Cricetinae,
pubmed-meshheading:8974007-Histocompatibility Antigens Class I,
pubmed-meshheading:8974007-Humans,
pubmed-meshheading:8974007-Hybrid Cells,
pubmed-meshheading:8974007-Mice,
pubmed-meshheading:8974007-Molecular Sequence Data,
pubmed-meshheading:8974007-Peptide Fragments,
pubmed-meshheading:8974007-Protein Structure, Tertiary,
pubmed-meshheading:8974007-Receptors, Interferon,
pubmed-meshheading:8974007-Recombinant Fusion Proteins,
pubmed-meshheading:8974007-Sequence Homology, Amino Acid,
pubmed-meshheading:8974007-Species Specificity
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pubmed:year |
1996
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pubmed:articleTitle |
The intracellular domain of the second chain of the interferon-gamma receptor is interchangeable between species.
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pubmed:affiliation |
Department of Molecular Genetics and Microbiology, UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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