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rdf:type |
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lifeskim:mentions |
umls-concept:C0005528,
umls-concept:C0007603,
umls-concept:C0009545,
umls-concept:C0086418,
umls-concept:C0205374,
umls-concept:C0205431,
umls-concept:C0449444,
umls-concept:C0542341,
umls-concept:C0596138,
umls-concept:C0597170,
umls-concept:C1325742,
umls-concept:C1334043,
umls-concept:C1706937,
umls-concept:C1710082
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pubmed:issue |
6
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pubmed:dateCreated |
1997-3-13
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pubmed:abstractText |
We have previously shown that the membrane attack complex (MAC) of complement stimulates cell proliferation and that insertion of homologous MAC into the membranes of endothelial cells results in the release of potent mitogens, including basic fibroblast growth factor (bFGF). The mechanism of secretion of bFGF and other polypeptides devoid of signal peptides, such as interleukin 1 (IL-1) is still an open problem in cell biology. We have hypothesized that the homologous MAC pore itself could constitute a transient route for the diffusion of biologically active macromolecules in and out of the target cells.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8972490-1066698,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8972490-1721817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8972490-1721819,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8972490-1849658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8972490-1902591,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8972490-1998698,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8972490-2015253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8972490-2049070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8972490-2139259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8972490-2335567,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8972490-2469439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8972490-2475570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8972490-2690818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8972490-2706268,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8972490-2760113,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8972490-281715,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8972490-3403718,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8972490-3545490,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8972490-3548335,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8972490-3682767,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8972490-3968432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8972490-490624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8972490-570203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8972490-6245139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8972490-6286757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8972490-7035559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8972490-7495498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8972490-7503241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8972490-7534659,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8972490-7701572,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8972490-8113689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8972490-8486768,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8972490-8834497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8972490-8963725
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Complement Membrane Attack Complex,
http://linkedlifedata.com/resource/pubmed/chemical/Complement System Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Dextrans,
http://linkedlifedata.com/resource/pubmed/chemical/Fibroblast Growth Factor 2,
http://linkedlifedata.com/resource/pubmed/chemical/Fluorescein-5-isothiocyanate,
http://linkedlifedata.com/resource/pubmed/chemical/Hemoglobins,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Liposomes,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/fluorescein isothiocyanate dextran
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1076-1551
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
755-65
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8972490-Biological Transport,
pubmed-meshheading:8972490-Cells, Cultured,
pubmed-meshheading:8972490-Complement Membrane Attack Complex,
pubmed-meshheading:8972490-Complement System Proteins,
pubmed-meshheading:8972490-Dextrans,
pubmed-meshheading:8972490-Erythrocyte Membrane,
pubmed-meshheading:8972490-Fibroblast Growth Factor 2,
pubmed-meshheading:8972490-Fluorescein-5-isothiocyanate,
pubmed-meshheading:8972490-Hemoglobins,
pubmed-meshheading:8972490-Humans,
pubmed-meshheading:8972490-Immunoglobulin G,
pubmed-meshheading:8972490-Interferon-gamma,
pubmed-meshheading:8972490-Interleukin-1,
pubmed-meshheading:8972490-Liposomes,
pubmed-meshheading:8972490-Microscopy, Fluorescence,
pubmed-meshheading:8972490-Peptides,
pubmed-meshheading:8972490-Umbilical Cord
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pubmed:year |
1996
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pubmed:articleTitle |
The transient pore formed by homologous terminal complement complexes functions as a bidirectional route for the transport of autocrine and paracrine signals across human cell membranes.
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