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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1997-3-17
|
| pubmed:abstractText |
FIV is a lentivirus of domestic cats that causes a spectrum of diseases that is remarkably similar to the clinical syndrome produced by HIV infection in people. Both HIV and FIV has been shown to cause neurologic dysfunction. Specific Pathogen-Free (SPF) cats were placed into one of three groups: FIV-PPR infected; DU-FIV-PPR (a dUTPase mutant of the FIV-PPR clone) infected; or an age-matched control group. In both infected groups, the general clinical signs of infection included lymphadenopathy, oral ulcerations, rough hair coat, and conjuntivitis. Specific neurological changes in the FIV-PPR infected cats included hind limb paresis; delayed righting and pupillary reflexes; behavioral changes; delayed visual and auditory evoked potentials; decreased spinal and peripheral nerve conduction velocities; and marked alterations in sleep patterns. Most of these changes were also observed in the DU-FIV-PPR infected cats. However, these cats tended to have a slightly less severe disease. In this study, we have demonstrated that an infectious molecular clone of FIV closely parallels the disease course of wild type FIV-infected cats. By using a knockout gene mutant of this clone, we were able to demonstrate that the dUTPase gene is not essential for neuropathogenesis. Further use of the FIV-PPR clone should prove useful in determining the essential viral elements that are important in the neuropathogenesis of lentiviral infections.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
1355-0284
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
2
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
388-96
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:8972420-Animals,
pubmed-meshheading:8972420-Cats,
pubmed-meshheading:8972420-Cloning, Molecular,
pubmed-meshheading:8972420-Electroencephalography,
pubmed-meshheading:8972420-Evoked Potentials, Auditory, Brain Stem,
pubmed-meshheading:8972420-Evoked Potentials, Somatosensory,
pubmed-meshheading:8972420-Feline Acquired Immunodeficiency Syndrome,
pubmed-meshheading:8972420-Genes, Viral,
pubmed-meshheading:8972420-Immunodeficiency Virus, Feline,
pubmed-meshheading:8972420-Mutagenesis,
pubmed-meshheading:8972420-Nervous System Diseases,
pubmed-meshheading:8972420-Neural Conduction,
pubmed-meshheading:8972420-Peripheral Nerves,
pubmed-meshheading:8972420-Pyrophosphatases,
pubmed-meshheading:8972420-Sleep,
pubmed-meshheading:8972420-Spinal Cord,
pubmed-meshheading:8972420-Virulence
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Neurologic dysfunctions caused by a molecular clone of feline immunodeficiency virus, FIV-PPR.
|
| pubmed:affiliation |
Neuropharmacology, Scripps Research Institute, La Jolla California 92037, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|