| pubmed-article:8971014 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8971014 | lifeskim:mentions | umls-concept:C0014644 | lld:lifeskim |
| pubmed-article:8971014 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:8971014 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:8971014 | lifeskim:mentions | umls-concept:C0039195 | lld:lifeskim |
| pubmed-article:8971014 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:8971014 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:8971014 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:8971014 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:8971014 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:8971014 | pubmed:dateCreated | 1997-1-23 | lld:pubmed |
| pubmed-article:8971014 | pubmed:abstractText | Persistent Epstein-Barr virus (EBV) infection is primarily controlled by HLA class I-restricted memory cytotoxic T-cell (CTL) responses which can be reactivated in vitro by stimulation of peripheral blood lymphocytes with autologous lymphoblastoid cell lines. During an investigation of a donor infected by both type A and type B EBV, CTL specific for type B EBV were isolated. The CTL were found to recognize an epitope encoded by the EBNA-6B gene. The minimal epitope sequence was identified as QNGALAINTF, corresponding to residues 213 to 222 in the EBNA-6B protein, and presentation of this epitope was shown to be via HLA B62 (B15). This is the first report of the characterization of an epitope that is EBV type B specific. CTL recognizing sequences common to type A and type B EBV were identified as well. A cross-reactive epitope recognized by these CTL was encoded within the EBNA-6 gene of both type A and type B. This minimal sequence for this epitope was LLDFVRFMGV (residues 284 to 293 in both types), and the epitope was restricted through HLA A*0201. This second epitope sequence overlaps with a published EBV B44-restricted epitope (EENLLDFVRF). The implications of these findings are discussed with respect to the design and efficacy of epitope-based vaccines. | lld:pubmed |
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| pubmed-article:8971014 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8971014 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8971014 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8971014 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8971014 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8971014 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8971014 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:8971014 | pubmed:author | pubmed-author:CrossSS | lld:pubmed |
| pubmed-article:8971014 | pubmed:author | pubmed-author:MossD JDJ | lld:pubmed |
| pubmed-article:8971014 | pubmed:author | pubmed-author:BuckMM | lld:pubmed |
| pubmed-article:8971014 | pubmed:author | pubmed-author:SculleyT BTB | lld:pubmed |
| pubmed-article:8971014 | pubmed:author | pubmed-author:BensonE MEM | lld:pubmed |
| pubmed-article:8971014 | pubmed:author | pubmed-author:KernB ABA | lld:pubmed |
| pubmed-article:8971014 | pubmed:author | pubmed-author:SilinsS LSL | lld:pubmed |
| pubmed-article:8971014 | pubmed:author | pubmed-author:KienzleNN | lld:pubmed |
| pubmed-article:8971014 | pubmed:author | pubmed-author:CouparBB | lld:pubmed |
| pubmed-article:8971014 | pubmed:author | pubmed-author:BurrowsJ MJM | lld:pubmed |
| pubmed-article:8971014 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8971014 | pubmed:volume | 70 | lld:pubmed |
| pubmed-article:8971014 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8971014 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8971014 | pubmed:pagination | 8858-64 | lld:pubmed |
| pubmed-article:8971014 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8971014 | pubmed:year | 1996 | lld:pubmed |
