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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1997-1-23
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pubmed:abstractText |
Persistent Epstein-Barr virus (EBV) infection is primarily controlled by HLA class I-restricted memory cytotoxic T-cell (CTL) responses which can be reactivated in vitro by stimulation of peripheral blood lymphocytes with autologous lymphoblastoid cell lines. During an investigation of a donor infected by both type A and type B EBV, CTL specific for type B EBV were isolated. The CTL were found to recognize an epitope encoded by the EBNA-6B gene. The minimal epitope sequence was identified as QNGALAINTF, corresponding to residues 213 to 222 in the EBNA-6B protein, and presentation of this epitope was shown to be via HLA B62 (B15). This is the first report of the characterization of an epitope that is EBV type B specific. CTL recognizing sequences common to type A and type B EBV were identified as well. A cross-reactive epitope recognized by these CTL was encoded within the EBNA-6 gene of both type A and type B. This minimal sequence for this epitope was LLDFVRFMGV (residues 284 to 293 in both types), and the epitope was restricted through HLA A*0201. This second epitope sequence overlaps with a published EBV B44-restricted epitope (EENLLDFVRF). The implications of these findings are discussed with respect to the design and efficacy of epitope-based vaccines.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8971014-1319456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8971014-1319577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8971014-1321443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8971014-1331531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8971014-1333480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8971014-1336962,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8971014-1377222,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8971014-1695259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8971014-1722774,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8971014-214405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8971014-2158098,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8971014-2162115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8971014-2165133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8971014-2166806,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/8971014-2548326,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8971014-2571010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8971014-2830541,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8971014-2981780,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/8971014-3030940,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8971014-3119718,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/8971014-4332899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8971014-4894385,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8971014-6066443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8971014-6088089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8971014-6088142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8971014-6090321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8971014-6104142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8971014-6209719,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/8971014-7532548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8971014-7538538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8971014-7542549,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8971014-7565411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8971014-7609055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8971014-7694640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8971014-7890324,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/8971014-7946041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8971014-8030259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8971014-8113743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8971014-8113767,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8971014-8195718
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
70
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
8858-64
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8971014-Adolescent,
pubmed-meshheading:8971014-Antigens, Viral,
pubmed-meshheading:8971014-B-Lymphocytes,
pubmed-meshheading:8971014-Cells, Cultured,
pubmed-meshheading:8971014-Cross Reactions,
pubmed-meshheading:8971014-Epitopes, B-Lymphocyte,
pubmed-meshheading:8971014-Epitopes, T-Lymphocyte,
pubmed-meshheading:8971014-HLA-A Antigens,
pubmed-meshheading:8971014-HLA-B Antigens,
pubmed-meshheading:8971014-Herpesvirus 4, Human,
pubmed-meshheading:8971014-Humans,
pubmed-meshheading:8971014-Infectious Mononucleosis,
pubmed-meshheading:8971014-T-Lymphocytes, Cytotoxic
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pubmed:year |
1996
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