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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1997-3-24
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pubmed:abstractText |
Occupancy of integrin adhesion receptors can alter the functions of other integrins and cause partition of the ligand-occupied integrin into focal adhesions. Ligand binding also changes the conformation of integrin extracellular domains. To explore the relationship between ligand-induced conformational change and integrin signaling, we examined the effect of ligands specific for integrin alpha IIb beta 3 on the functions of target integrins alpha 5 beta 1 and alpha 2 beta 1. We report that binding of integrin-specific ligands to a suppressive integrin can inhibit the function of other target integrins (trans-dominant inhibition). Trans-dominant inhibition is due to a blockade of integrin signaling. Furthermore, this inhibition involves both a conformational change in the extracellular domain and the presence of the beta cytoplasmic tail in the suppressive integrin. Similarly, ligand-induced recruitment of alpha IIb beta 3 to focal adhesions also involves a conformational rearrangement of its extracellular domain. These findings imply that the ligand-induced conformational changes can propagate from an integrin's extracellular to its intracellular face. Trans-dominant inhibition by integrin ligands may coordinate integrin signaling and can lead to unexpected biological effects of integrin-specific inhibitors.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-1373145,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-1373972,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-1447740,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-14731732,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-1500442,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-1517241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-1527012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-1555235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-1627801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-1651088,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-1707057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-1948065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-2100193,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-2318856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-2392682,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-2455654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-2457583,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-2752106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-2785522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-2957377,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-3875376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-4012302,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-6229297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-6325925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-6826726,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-7510712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-7512751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-7518428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-7525603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-7537277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-7541142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-7542651,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-7542659,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-7560073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-7579714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-7678112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-7690620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-7693683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-7759482,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-7846531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-7929213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-8034576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-8063864,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-8106557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-8143343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-8187171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-8219222,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-8257797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-8314843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-8389452,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-8436601,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-8458867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-8521488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-8636068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8970156-8689569
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1059-1524
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1939-51
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8970156-Humans,
pubmed-meshheading:8970156-Animals,
pubmed-meshheading:8970156-Cytoplasm,
pubmed-meshheading:8970156-Rabbits,
pubmed-meshheading:8970156-Cricetinae,
pubmed-meshheading:8970156-Protein Conformation,
pubmed-meshheading:8970156-CHO Cells,
pubmed-meshheading:8970156-Ligands,
pubmed-meshheading:8970156-Signal Transduction,
pubmed-meshheading:8970156-Apoptosis,
pubmed-meshheading:8970156-Receptors, Fibronectin,
pubmed-meshheading:8970156-Receptors, Collagen,
pubmed-meshheading:8970156-Integrins,
pubmed-meshheading:8970156-Platelet Glycoprotein GPIIb-IIIa Complex
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