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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1997-1-16
|
| pubmed:abstractText |
In water, the inertial collapse of a bubble is more violent after expansion by a negative acoustic pressure pulse than when directly compressed by a positive pulse of equal amplitude and duration. In tissues, gas bodies may be limited in their ability to expand and, therefore, the relatively strong effectiveness of negative pressure excursions may be tempered. To determine the relative effectiveness of positive and negative pressure pulses in vivo, the mortality rate of Drosophila larvae was determined as a function of exposure to microsecond length, nearly unipolar, positive and negative pressure pulses. Air-filled tracheae in the larvae serve as biological models of small, constrained bubbles. Death from exposure to ultrasound has previously been correlated with the presence of air in the respiratory system. The degree of hemorrhage in murine lung was also compared using positive and negative pulses. The high sensitivity of lung to exposure to ultrasound also depends on its gas content. The mammalian lung is much more complex than the respiratory system of insect larvae and, at the present time, it is not clear that acoustic cavitation is the physical mechanism for hemorrhage. A spark from an electrohydraulic lithotripter was used to produce a spherically diverging positive pulse. An isolated negative pulse was generated by reflection of the lithotripter pulse from a pressure release interface. Pulse amplitudes ranging from 1 to 5 MPa were obtained by changing the proximity of the source to the biological target. For both biological effects, the positive pulse was found to be at least as damaging as the negative pulse at comparable temporal peak pressure levels. These observations may be relevant to an evaluation of the mechanical index (MI) as an exposure parameter for tissues including lung since MI currently is defined in terms of the magnitude of the negative pressure in the ultrasound field.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0001-4966
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
100
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3941-6
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading | |
| pubmed:year |
1996
|
| pubmed:articleTitle |
Bioeffects of positive and negative acoustic pressures in vivo.
|
| pubmed:affiliation |
Department of Mechanical Engineering, University of Texas at Austin 78713-8029, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|