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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1977-10-14
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pubmed:abstractText |
Sexual receptivity induced in ovariectomized CD-1 mice with chronic daily administration of estradiol benzoate (E2 B) was blocked by concurrent administration of the 5 alpha-reduced androgen, dihydrotestosterone (DHT). Receptivity was restored in these females with progesterone-, but not with dihydroprogesterone-priming 6 hr prior to testing. Delaying the DHT injections until 12 hr after the E2 B injections greatly reduced its inhibitory properties. Receptivity in E2 B-primed females was also blocked by concurrent treatment with cyproterone acetate and 3 alpha-, but not 3 beta-adrostanediol. Pretreatment with DHT, or 3 alpha- or 3 beta-androstanediol failed to consistently affects 3H-estradiol accumulation in crude nuclear and supernatant fractions from brain and pituitary.
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pubmed:keyword |
http://linkedlifedata.com/resource/pubmed/keyword/Androgens--administraction and dosage,
http://linkedlifedata.com/resource/pubmed/keyword/Androgens--side effects,
http://linkedlifedata.com/resource/pubmed/keyword/Animals, Laboratory,
http://linkedlifedata.com/resource/pubmed/keyword/Behavior,
http://linkedlifedata.com/resource/pubmed/keyword/Biology,
http://linkedlifedata.com/resource/pubmed/keyword/Clinical Research,
http://linkedlifedata.com/resource/pubmed/keyword/Contraception,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents...,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents...,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents...,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents, Female--side...,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive...,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents--side effects,
http://linkedlifedata.com/resource/pubmed/keyword/Cyproterone...,
http://linkedlifedata.com/resource/pubmed/keyword/Cyproterone Acetate--side effects,
http://linkedlifedata.com/resource/pubmed/keyword/Endocrine System,
http://linkedlifedata.com/resource/pubmed/keyword/Estradiol Benzoate--administraction...,
http://linkedlifedata.com/resource/pubmed/keyword/Estradiol Benzoate--side effects,
http://linkedlifedata.com/resource/pubmed/keyword/Estrogens,
http://linkedlifedata.com/resource/pubmed/keyword/Family Planning,
http://linkedlifedata.com/resource/pubmed/keyword/Female Sterilization,
http://linkedlifedata.com/resource/pubmed/keyword/Gynecologic Surgery,
http://linkedlifedata.com/resource/pubmed/keyword/Hormone Antagonists,
http://linkedlifedata.com/resource/pubmed/keyword/Hormones,
http://linkedlifedata.com/resource/pubmed/keyword/Ovariectomy,
http://linkedlifedata.com/resource/pubmed/keyword/Physiology,
http://linkedlifedata.com/resource/pubmed/keyword/Progestational Hormones,
http://linkedlifedata.com/resource/pubmed/keyword/Progesterone--administraction and...,
http://linkedlifedata.com/resource/pubmed/keyword/Progesterone--side effects,
http://linkedlifedata.com/resource/pubmed/keyword/Research Methodology,
http://linkedlifedata.com/resource/pubmed/keyword/Sex Behavior,
http://linkedlifedata.com/resource/pubmed/keyword/Stanolone--administraction and dosage,
http://linkedlifedata.com/resource/pubmed/keyword/Stanolone--side effects,
http://linkedlifedata.com/resource/pubmed/keyword/Surgery,
http://linkedlifedata.com/resource/pubmed/keyword/Treatment,
http://linkedlifedata.com/resource/pubmed/keyword/Urogenital Surgery
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
May
|
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pubmed:issn |
0091-3057
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
6
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|
pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
521-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:896889-20-alpha-Dihydroprogesterone,
pubmed-meshheading:896889-Androgens,
pubmed-meshheading:896889-Androstane-3,17-diol,
pubmed-meshheading:896889-Animals,
pubmed-meshheading:896889-Brain,
pubmed-meshheading:896889-Castration,
pubmed-meshheading:896889-Cyproterone,
pubmed-meshheading:896889-Dihydrotestosterone,
pubmed-meshheading:896889-Drug Interactions,
pubmed-meshheading:896889-Estradiol,
pubmed-meshheading:896889-Female,
pubmed-meshheading:896889-Male,
pubmed-meshheading:896889-Mice,
pubmed-meshheading:896889-Pituitary Gland,
pubmed-meshheading:896889-Progesterone,
pubmed-meshheading:896889-Progestins,
pubmed-meshheading:896889-Sexual Behavior, Animal
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pubmed:year |
1977
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pubmed:articleTitle |
Estrogen-induced sexual receptivity and localization of 3H-estradiol in brains of female mice: effects of 5 alpha-reduced androgens, progestins and cyproterone acetate.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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