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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1997-1-15
|
| pubmed:abstractText |
Neurolytic agents such as phenol (5% to 10%) and absolute alcohol have long been used clinically to destroy the pathogenic nerve regions that manifest pain. Both phenol and alcohol are highly destructive to nerve fibers. However, these agents exert only weak local anesthetic effects and therefore are difficult to administer to alert patients without pain. This report describes a tetracaine derivative that displays both local anesthetic and neurolytic properties. Studies with such a compound may lead to the design of neurolytic agents that are more effective and more easily administered than phenol and alcohol.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0003-3022
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
85
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1386-94
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:8968186-Anesthetics, Local,
pubmed-meshheading:8968186-Animals,
pubmed-meshheading:8968186-Autonomic Nervous System,
pubmed-meshheading:8968186-Cells, Cultured,
pubmed-meshheading:8968186-Nerve Block,
pubmed-meshheading:8968186-Pain,
pubmed-meshheading:8968186-Rats,
pubmed-meshheading:8968186-Sciatic Nerve,
pubmed-meshheading:8968186-Sodium Channels,
pubmed-meshheading:8968186-Tetracaine
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
N-butyl tetracaine as a neurolytic agent for ultralong sciatic nerve block.
|
| pubmed:affiliation |
Department of Anesthesia, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. Wang@zeus.bwh.harvard.edu
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|