Linked Life Data

8968026

Source:http://linkedlifedata.com/resource/pubmed/id/8968026

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1997-5-13
pubmed:abstractText
Acoustic velocity measurements are used to estimate tissue-level bone strength after fluoride therapy for osteoporosis. However, acoustic measurements provide information about elasticity, not strength, and bone elasticity does not necessarily correlate with bone strength at a tissue level. The current study was undertaken to evaluate the effects of fluoride treatment on tissue-level acoustic velocities, and to determine the relationship between acoustic velocity and bone strength measured in the femur, femoral neck, and spine. Young adult rabbits were treated with either 0 or 100 parts per million of fluoride in their drinking water for six months. After treatment, the bones were harvested for measurement of tissue fluoride, bone strength, and acoustic properties. Acoustic velocities were measured in the femoral midshaft using an acoustic microscope with a 50 MHz transducer. Both longitudinal and transverse velocities were measured. After the initial acoustic measurements the bone specimens were treated to remove either the organic matrix or mineral, and the acoustic measurements were repeated. Fluoride treatment increased bone fluoride levels 7-8 fold and reduced all biomechanical parameters. Most notably the fracture force of the femoral neck was reduced by 25% (p < 0.005), and the fracture stress of the L-5 vertebra was reduced by 19% (p < 0.05). Fluoride treatment had no significant effect on any of the measured acoustic velocities. The elastic anisotropy of the bone was decreased by demineralization (p < 0.0001) and increased by removal of the organic matrix (p < 0.0001), but unaffected by fluoride treatment. Acoustic measurements were not correlated with bone strength in the femoral neck or femoral midshaft. There was a positive correlation between the longitudinal velocity measured in the femur and the vertebral fracture stress, but this was the only positive association between acoustic velocities and strength measurements. These data cast doubt on the utility of high frequency (>2 MHz) acoustic measurements for evaluating the efficacy of fluoride therapy, especially in the hip.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
8756-3282
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
603-7
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Reductions in bone strength after fluoride treatment are not reflected in tissue-level acoustic measurements.
pubmed:affiliation
Biomechanics and Biomaterials Research Center, Indiana University Medical Center, Indianapolis 46202, USA. turnerch@indyvax.iupui.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.