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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4 Pt 2
|
| pubmed:dateCreated |
1996-12-4
|
| pubmed:abstractText |
The 20-min rate of gastric emptying of a noncaloric solution and c-fos expression detected by immunohistochemistry in the brain were monitored 3 h after abdominal surgery performed under 10-min enflurane anesthesia in rats. Abdominal surgery (laparotomy and 1-min manipulation of the cecum) decreased gastric emptying from 60.8 +/- 3.4 to 25.9 +/- 3.4%. Capsaicin applied to the celiac/superior mesenteric ganglia 2 wk before the experiment reduced the delay in gastric emptying induced by abdominal surgery (46.3 +/- 3.4%), whereas perivagal capsaicin application had no effect (23.6 +/- 7.9%). The corticotropin-releasing factor (CRF) antagonist [D-Phe12, Nle21,38,C alpha MeLeu37]CRF-(12--41) injected intracisternally (10-20 micrograms) prevented postoperative gastroparesis induced by surgery, while having no effect on basal gastric emptying. Abdominal surgery increased the number of Fos-positive cells in brain nuclei regulating autonomic outflow: the nucleus of the solitary tract, locus ceruleus, paraventricular nucleus, and supraoptic nucleus of the hypothalamus. These data indicate that capsaicin-sensitive splanchnic afferent fibers and activation of CRF receptors in the brain are part of the neuronal circuitry mediating gastric stasis 3 h after abdominal surgery.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0002-9513
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
270
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
R888-94
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:8967419-Abdomen,
pubmed-meshheading:8967419-Administration, Topical,
pubmed-meshheading:8967419-Animals,
pubmed-meshheading:8967419-Brain,
pubmed-meshheading:8967419-Capsaicin,
pubmed-meshheading:8967419-Cisterna Magna,
pubmed-meshheading:8967419-Corticotropin-Releasing Hormone,
pubmed-meshheading:8967419-Ganglia, Sympathetic,
pubmed-meshheading:8967419-Gastric Emptying,
pubmed-meshheading:8967419-Gastroparesis,
pubmed-meshheading:8967419-Immunohistochemistry,
pubmed-meshheading:8967419-Injections,
pubmed-meshheading:8967419-Male,
pubmed-meshheading:8967419-Neural Pathways,
pubmed-meshheading:8967419-Postoperative Complications,
pubmed-meshheading:8967419-Proto-Oncogene Proteins c-fos,
pubmed-meshheading:8967419-Rats,
pubmed-meshheading:8967419-Rats, Sprague-Dawley
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Neuronal pathways involved in abdominal surgery-induced gastric ileus in rats.
|
| pubmed:affiliation |
Center for Ulcer Research and Education/Digestive Disease Research Center, West Los Angeles Veterans Affairs Medical Center, California, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|